Myocardial ischaemia–reperfusion injury and cardioprotection in perspective
G Heusch - Nature Reviews Cardiology, 2020 - nature.com
Despite the increasing use and success of interventional coronary reperfusion strategies,
morbidity and mortality from acute myocardial infarction are still substantial. Myocardial …
morbidity and mortality from acute myocardial infarction are still substantial. Myocardial …
Myocardial ischemia-reperfusion injury and the influence of inflammation
Acute myocardial infarction is caused by a sudden coronary artery occlusion and leads to
ischemia in the corresponding myocardial territory which generally results in myocardial …
ischemia in the corresponding myocardial territory which generally results in myocardial …
Multitarget Strategies to Reduce Myocardial Ischemia/Reperfusion Injury: JACC Review Topic of the Week
Many treatments have been identified that confer robust cardioprotection in experimental
animal models of acute ischemia and reperfusion injury. However, translation of these …
animal models of acute ischemia and reperfusion injury. However, translation of these …
Mitochondria in acute myocardial infarction and cardioprotection
Acute myocardial infarction (AMI) and the heart failure (HF) that often follows are among the
leading causes of death and disability worldwide. As such, new treatments are needed to …
leading causes of death and disability worldwide. As such, new treatments are needed to …
[HTML][HTML] Effect of remote ischaemic conditioning on clinical outcomes in patients with acute myocardial infarction (CONDI-2/ERIC-PPCI): a single-blind randomised …
DJ Hausenloy, RK Kharbanda, UK Møller, M Ramlall… - The Lancet, 2019 - thelancet.com
Background Remote ischaemic conditioning with transient ischaemia and reperfusion
applied to the arm has been shown to reduce myocardial infarct size in patients with ST …
applied to the arm has been shown to reduce myocardial infarct size in patients with ST …
Guidelines for experimental models of myocardial ischemia and infarction
Myocardial infarction is a prevalent major cardiovascular event that arises from myocardial
ischemia with or without reperfusion, and basic and translational research is needed to …
ischemia with or without reperfusion, and basic and translational research is needed to …
Practical guidelines for rigor and reproducibility in preclinical and clinical studies on cardioprotection
The potential for ischemic preconditioning to reduce infarct size was first recognized more
than 30 years ago [180]. Despite extension of the concept to ischemic postcondition‑ing …
than 30 years ago [180]. Despite extension of the concept to ischemic postcondition‑ing …
The pathophysiology of acute myocardial infarction and strategies of protection beyond reperfusion: a continual challenge
G Heusch, BJ Gersh - European heart journal, 2017 - academic.oup.com
The incidence of ST segment elevation myocardial infarction (STEMI) has decreased over
the last two decades in developed countries, but mortality from STEMI despite widespread …
the last two decades in developed countries, but mortality from STEMI despite widespread …
Evolving therapies for myocardial ischemia/reperfusion injury
The damage inflicted on the myocardium during acute myocardial infarction is the result of 2
processes: ischemia and subsequent reperfusion (ischemia/reperfusion injury). During the …
processes: ischemia and subsequent reperfusion (ischemia/reperfusion injury). During the …
Targeting vascular (endothelial) dysfunction
A Daiber, S Steven, A Weber… - British journal of …, 2017 - Wiley Online Library
Cardiovascular diseases are major contributors to global deaths and disability‐adjusted life
years, with hypertension a significant risk factor for all causes of death. The endothelium that …
years, with hypertension a significant risk factor for all causes of death. The endothelium that …