Myocardial ischaemia–reperfusion injury and cardioprotection in perspective

G Heusch - Nature Reviews Cardiology, 2020 - nature.com
Despite the increasing use and success of interventional coronary reperfusion strategies,
morbidity and mortality from acute myocardial infarction are still substantial. Myocardial …

Myocardial ischemia-reperfusion injury and the influence of inflammation

M Algoet, S Janssens, U Himmelreich, W Gsell… - Trends in cardiovascular …, 2023 - Elsevier
Acute myocardial infarction is caused by a sudden coronary artery occlusion and leads to
ischemia in the corresponding myocardial territory which generally results in myocardial …

Multitarget Strategies to Reduce Myocardial Ischemia/Reperfusion Injury: JACC Review Topic of the Week

SM Davidson, P Ferdinandy, I Andreadou… - Journal of the American …, 2019 - jacc.org
Many treatments have been identified that confer robust cardioprotection in experimental
animal models of acute ischemia and reperfusion injury. However, translation of these …

Mitochondria in acute myocardial infarction and cardioprotection

CJA Ramachandra, S Hernandez-Resendiz… - …, 2020 - thelancet.com
Acute myocardial infarction (AMI) and the heart failure (HF) that often follows are among the
leading causes of death and disability worldwide. As such, new treatments are needed to …

[HTML][HTML] Effect of remote ischaemic conditioning on clinical outcomes in patients with acute myocardial infarction (CONDI-2/ERIC-PPCI): a single-blind randomised …

DJ Hausenloy, RK Kharbanda, UK Møller, M Ramlall… - The Lancet, 2019 - thelancet.com
Background Remote ischaemic conditioning with transient ischaemia and reperfusion
applied to the arm has been shown to reduce myocardial infarct size in patients with ST …

Guidelines for experimental models of myocardial ischemia and infarction

ML Lindsey, R Bolli, JM Canty Jr… - American Journal …, 2018 - journals.physiology.org
Myocardial infarction is a prevalent major cardiovascular event that arises from myocardial
ischemia with or without reperfusion, and basic and translational research is needed to …

Practical guidelines for rigor and reproducibility in preclinical and clinical studies on cardioprotection

HE Bøtker, D Hausenloy, I Andreadou… - Basic research in …, 2018 - Springer
The potential for ischemic preconditioning to reduce infarct size was first recognized more
than 30 years ago [180]. Despite extension of the concept to ischemic postcondition‑ing …

The pathophysiology of acute myocardial infarction and strategies of protection beyond reperfusion: a continual challenge

G Heusch, BJ Gersh - European heart journal, 2017 - academic.oup.com
The incidence of ST segment elevation myocardial infarction (STEMI) has decreased over
the last two decades in developed countries, but mortality from STEMI despite widespread …

Evolving therapies for myocardial ischemia/reperfusion injury

B Ibáñez, G Heusch, M Ovize, F Van de Werf - Journal of the American …, 2015 - jacc.org
The damage inflicted on the myocardium during acute myocardial infarction is the result of 2
processes: ischemia and subsequent reperfusion (ischemia/reperfusion injury). During the …

Targeting vascular (endothelial) dysfunction

A Daiber, S Steven, A Weber… - British journal of …, 2017 - Wiley Online Library
Cardiovascular diseases are major contributors to global deaths and disability‐adjusted life
years, with hypertension a significant risk factor for all causes of death. The endothelium that …