A substantial and diverse body of literature suggests that the pathophysiology of
schizophrenia is related to deficits of bioenergetic function. While antipsychotics are an …

Translational genomics aims to improve human health by building on discoveries made
through genetics research and applying them in the clinical setting. This progress has been …

These updated guidelines from the British Association for Psychopharmacology replace the
original version published in 2011. They address the scope and targets of pharmacological …

Importance The potential association of schizophrenia with distinct retinal changes is of
clinical interest but has been challenging to investigate because of a lack of sufficiently large …

The mortality rate of patients with schizophrenia is high, and life expectancy is shorter by 10
to 20 years. Metabolic abnormalities including type 2 diabetes mellitus (T2DM) are among …

Importance Cardiometabolic disorders often occur concomitantly with psychosis and
depression, contribute to high mortality rates, and are detectable from the onset of the …

Objective: Schizophrenia is associated with increased risk of cardiovascular disease (CVD),
although there is variation in risk among individuals. There are indications of shared genetic …

Having a psychiatric disorder may increase the risk of develo** type 2 diabetes [T2D] and
this umbrella review aims to determine whether people with a psychiatric disorder have an …

Psychiatric disorders are highly heritable and associated with a wide variety of social
adversity and physical health problems. Using genetic liability (rather than phenotypic …

In search of interventions targeting brain dysfunction and underlying cognitive impairment in
schizophrenia, we look at the brain and beyond to the potential role of dysfunctional …