Inbreeding depression—the reduced survival and fertility of offspring of related individuals—
occurs in wild animal and plant populations as well as in humans, indicating that genetic …

The effective size of a population, N e, determines the rate of change in the composition of a
population caused by genetic drift, which is the random sampling of genetic variants in a …

Stochastic simulation is a key tool in population genetics, since the models involved are
often analytically intractable and simulation is usually the only way of obtaining ground-truth …

Abstract Whole-genome duplication (WGD), or polyploidy, events are widespread and
significant in the evolutionary history of angiosperms. However, empirical evidence for …

Structural variants (SVs) are a largely unexplored feature of plant genomes. Little is known
about the type and size of SVs, their distribution among individuals and, especially, their …

Abstract Approximately 2–4% of genetic material in human populations outside Africa is
derived from Neanderthals who interbred with anatomically modern humans. Recent studies …

Genetic studies have revealed thousands of loci predisposing to hundreds of human
diseases and traits, revealing important biological pathways and defining novel therapeutic …

Viruses interact with hundreds to thousands of proteins in mammals, yet adaptation against
viruses has only been studied in a few proteins specialized in antiviral defense. Whether …

The field of population genomics has grown rapidly in response to the recent advent of
affordable, large-scale sequencing technologies. As opposed to the situation during the …

Each human carries a large number of deleterious mutations. Together, these mutations
make a significant contribution to human disease. Identification of deleterious mutations …