Insights on the mechanism of bleomycin to induce lung injury and associated in vivo models: a review
Acute lung injury leads to the development of chronic conditions such as idiopathic
pulmonary fibrosis (IPF), chronic obstructive pulmonary disease (COPD), asthma as well as …
pulmonary fibrosis (IPF), chronic obstructive pulmonary disease (COPD), asthma as well as …
[HTML][HTML] Inhibition of antiapoptotic BCL-2 proteins with ABT-263 induces fibroblast apoptosis, reversing persistent pulmonary fibrosis
JC Cooley, N Javkhlan, JA Wilson, DG Foster… - JCI insight, 2023 - ncbi.nlm.nih.gov
Patients with progressive fibrosing interstitial lung diseases (PF-ILDs) carry a poor prognosis
and have limited therapeutic options. A hallmark feature is fibroblast resistance to apoptosis …
and have limited therapeutic options. A hallmark feature is fibroblast resistance to apoptosis …
[HTML][HTML] Highlights on future treatments of IPF: clues and pitfalls
A Libra, E Sciacca, G Muscato, G Sambataro… - International Journal of …, 2024 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease characterized by irreversible
scarring of lung tissue, leading to death. Despite recent advancements in understanding its …
scarring of lung tissue, leading to death. Despite recent advancements in understanding its …
Extracellular vesicles derived from adipose stem cells alleviate systemic sclerosis by inhibiting tgf-β pathway
Systemic sclerosis is an autoimmune disease characterized by inflammatory reactions and
fibrosis. Myofibroblasts are considered therapeutic targets for preventing and reversing the …
fibrosis. Myofibroblasts are considered therapeutic targets for preventing and reversing the …
Chlorogenic acid attenuates idiopathic pulmonary fibrosis: An integrated analysis of network pharmacology, molecular docking, and experimental validation
JM Velázquez-Enríquez, JC Santos-Álvarez… - Biochemical and …, 2024 - Elsevier
Aims Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung condition, the
cause of which remains unknown and for which no effective therapeutic treatment is …
cause of which remains unknown and for which no effective therapeutic treatment is …
BCL-2 modulates IRE1α activation to attenuate endoplasmic reticulum stress and pulmonary fibrosis
CJ Le Saux, TC Ho, AM Brumwell… - American Journal of …, 2024 - atsjournals.org
BCL-2 family members are known to be implicated in survival in numerous biological
settings. Here, we provide evidence that in injury and repair processes in lungs, BCL-2 …
settings. Here, we provide evidence that in injury and repair processes in lungs, BCL-2 …
The matricellular protein CCN3 supports lung endothelial homeostasis and function
KR Betageri, PA Link, AJ Haak… - … of Physiology-Lung …, 2023 - journals.physiology.org
Aberrant vascular remodeling contributes to the progression of many aging-associated
diseases, including idiopathic pulmonary fibrosis (IPF), where heterogeneous capillary …
diseases, including idiopathic pulmonary fibrosis (IPF), where heterogeneous capillary …
Combination of niclosamide and pirfenidone alleviates pulmonary fibrosis by inhibiting oxidative stress and MAPK/Nf-κB and STATs regulated genes
The pathogenesis of pulmonary fibrosis (PF) is extremely complex and involves numerous
intersecting pathways. The successful management of PF may require combining multiple …
intersecting pathways. The successful management of PF may require combining multiple …
Getting the Timing Right: Controlling BCL-2 Inhibition as an Antifibrotic Therapy
JC Cooley, EF Redente - American Journal of Respiratory Cell and …, 2024 - atsjournals.org
Progressive fibrosing interstitial lung diseases (PF-ILDs), such as idiopathic pulmonary
fibrosis (IPF), have pathophysiologic overlap, including accumulation of apoptosis-resistant …
fibrosis (IPF), have pathophysiologic overlap, including accumulation of apoptosis-resistant …
Cyclophosphamide combined with methylprednisolone ameliorates bleomycin-induced pulmonary fibrosis in rats through immunomodulatory mechanisms
Q Xu, Y Chen, M Tang, M Zhang, Y Liu, Z Li, R Ma… - 2022 - researchsquare.com
Background Idiopathic pulmonary fibrosis (IPF) is a distressing lung disorder with poor
prognosis and high mortality rates. Immune factors are currently recognized as pathogenic …
prognosis and high mortality rates. Immune factors are currently recognized as pathogenic …