A new and promising tool in membrane research is the detergent-free solubilization of
membrane proteins by styrene–maleic acid copolymers (SMAs). These amphipathic …

Membrane proteins that exist in lipid bilayers are not isolated molecular entities. The lipid
molecules that surround them play crucial roles in maintaining their full structural and …

Despite the great importance of membrane proteins, structural and functional studies of
these proteins present major challenges. A significant hurdle is the extraction of the …

A major obstacle in the study of membrane proteins is their solubilization in a stable and
active conformation when using detergents. Here, we explored a detergent-free approach to …

For some membrane proteins, detergent-mediated solubilization compromises protein
stability and functionality, often impairing biophysical and structural analyses. Hence …

A recent discovery in membrane research is the ability of styrene-maleic acid (SMA)
copolymers to solubilize membranes in the form of nanodisks allowing extraction and …

In the past few years there has been a growth in the use of nanoparticles for stabilizing lipid
membranes that contain embedded proteins. These bionanoparticles provide a solution to …

ABC (ATP-binding-cassette) transporters carry out many vital functions and are involved in
numerous diseases, but study of the structure and function of these proteins is often …

Membrane proteins perform a host of vital cellular functions. Deciphering the molecular
mechanisms whereby they fulfill these functions requires detailed biophysical and structural …

The styrene-maleic acid (SMA) copolymer is rapidly gaining attention as a tool in membrane
research, due to its ability to directly solubilize lipid membranes into nanodisk particles …