DNA single-strand break repair and human genetic disease
KW Caldecott - Trends in cell biology, 2022 - cell.com
DNA single-strand breaks (SSBs) are amongst the commonest DNA lesions arising in cells,
with many tens of thousands induced in each cell each day. SSBs arise not only from …
with many tens of thousands induced in each cell each day. SSBs arise not only from …
Structure and function of the histone chaperone FACT–Resolving FACTual issues
Abstract FAcilitates Chromatin Transcription (FACT) has been considered essential for
transcription through chromatin mostly based on cell-free experiments. However, FACT …
transcription through chromatin mostly based on cell-free experiments. However, FACT …
Calorie restriction modulates the transcription of genes related to stress response and longevity in human muscle: The CALERIE study
The lifespan extension induced by 40% caloric restriction (CR) in rodents is accompanied by
postponement of disease, preservation of function, and increased stress resistance. Whether …
postponement of disease, preservation of function, and increased stress resistance. Whether …
PARP power: a structural perspective on PARP1, PARP2, and PARP3 in DNA damage repair and nucleosome remodelling
L van Beek, É McClay, S Patel, M Schimpl… - International journal of …, 2021 - mdpi.com
Poly (ADP-ribose) polymerases (PARP) 1-3 are well-known multi-domain enzymes,
catalysing the covalent modification of proteins, DNA, and themselves. They attach mono-or …
catalysing the covalent modification of proteins, DNA, and themselves. They attach mono-or …
[HTML][HTML] Mechanism of PARP inhibitor resistance and potential overcoming strategies
PARP inhibitors (PARPi) are a kind of cancer therapy that targets poly (ADP-ribose)
polymerase. PARPi is the first clinically approved drug to exert synthetic lethality by …
polymerase. PARPi is the first clinically approved drug to exert synthetic lethality by …
The histone chaperone FACT coordinates H2A. X-dependent signaling and repair of DNA damage
S Piquet, F Le Parc, SK Bai, O Chevallier, S Adam… - Molecular cell, 2018 - cell.com
Safeguarding cell function and identity following a genotoxic stress challenge entails a tight
coordination of DNA damage signaling and repair with chromatin maintenance. How this …
coordination of DNA damage signaling and repair with chromatin maintenance. How this …
Single-strand break end resection in genome integrity: mechanism and regulation by APE2
DNA single-strand breaks (SSBs) occur more than 10,000 times per mammalian cell each
day, representing the most common type of DNA damage. Unrepaired SSBs compromise …
day, representing the most common type of DNA damage. Unrepaired SSBs compromise …
[HTML][HTML] CBL0137 activates ROS/BAX signaling to promote caspase-3/GSDME-dependent pyroptosis in ovarian cancer cells
C Yang, ZQ Wang, ZC Zhang, G Lou, WL ** - Biomedicine & …, 2023 - Elsevier
Curaxin CBL0137 was designed to regulate p53 and nuclear factor-κB simultaneously and
exhibits antitumor activity by inhibiting tumor cell proliferation and inducing apoptosis in …
exhibits antitumor activity by inhibiting tumor cell proliferation and inducing apoptosis in …
Effective inhibition of MYC-amplified group 3 medulloblastoma by FACT-targeted curaxin drug CBL0137
J Wang, Y Sui, Q Li, Y Zhao, X Dong, J Yang… - Cell Death & …, 2020 - nature.com
Medulloblastoma (MB) is the most common malignant pediatric brain tumor that can be
categorized into four major molecular subgroups. Group 3 MB with MYC amplification …
categorized into four major molecular subgroups. Group 3 MB with MYC amplification …
Poly (ADP-ribosyl) ation mediates early phase histone eviction at DNA lesions
G Yang, Y Chen, J Wu, SH Chen, X Liu… - Nucleic Acids …, 2020 - academic.oup.com
Nucleosomal histones are barriers to the DNA repair process particularly at DNA double-
strand breaks (DSBs). However, the molecular mechanism by which these histone barriers …
strand breaks (DSBs). However, the molecular mechanism by which these histone barriers …