How adhesive interactions between cells generate and maintain animal tissue structure
remains one of the most challenging and long-standing questions in cell and developmental …

In the early days of epithelial cell biology, researchers working with kidney and/or intestinal
epithelial cell lines and with hepatocytes described the biosynthetic and recycling routes …

Microtubules are highly dynamic structures whose regulation is crucial for cell division, cell
polarity, cell migration, or neuronal differentiation. Because they contribute to most cellular …

Mitotic spindle orientation can influence tissue organization and vice versa. Cells orient their
spindles by rotating them parallel or perpendicular to the cell–and hence the tissue–axis …

Microtubules are cytoskeletal elements known as drivers of directed cell migration, vesicle
and organelle trafficking, and mitosis. In this review, we discuss new research in the lens …

Cadherin-based intercellular adhesions are important determinants of proper tissue
architecture. These adhesions must be both stable and dynamic to maintain tissue integrity …

The cytoskeleton is crucially important for the assembly of cell-cell junctions and the
homeostatic regulation of their functions. Junctional proteins act, in turn, as anchors for …

Mechanisms by which microtubule plus ends interact with regions of cell–cell contact during
tissue development and morphogenesis are not fully understood. We characterize a …

Resolving phenotype variation within a population in response to environmental
perturbation is central to understanding biological adaptation. Relating meaningful adaptive …

In healthy individuals, any rise in blood glucose levels is rapidly countered by the release of
insulin from the β-cells of the pancreas which in turn promotes the uptake and storage of the …