The role of platelets in inflammation
There is growing recognition of the critical role of platelets in inflammation and immune
responses. Recent studies have indicated that antiplatelet medications may reduce mortality …
responses. Recent studies have indicated that antiplatelet medications may reduce mortality …
Aspirin-free strategies in cardiovascular disease and cardioembolic stroke prevention
In patients with manifestations of cardiovascular disease, acetylsalicylic acid (popularly
known as aspirin) has been the mainstay of treatment for decades owing to its capacity to …
known as aspirin) has been the mainstay of treatment for decades owing to its capacity to …
Protective effects of ticagrelor on myocardial injury after infarction
G Vilahur, M Gutiérrez, L Casani, L Varela… - Circulation, 2016 - Am Heart Assoc
Background: The P2Y12 receptor antagonist ticagrelor has been shown to be clinically
superior to clopidogrel. Although the underlying mechanisms remain elusive, ticagrelor may …
superior to clopidogrel. Although the underlying mechanisms remain elusive, ticagrelor may …
Platelet P2Y12 Inhibitors Reduce Systemic Inflammation and Its Prothrombotic Effects in an Experimental Human Model
MR Thomas, SN Outteridge, RA Ajjan… - … and Vascular Biology, 2015 - Am Heart Assoc
Objective—Clinical studies suggest that platelet P2Y12 inhibitors reduce mortality from
sepsis, although the underlying mechanisms have not been clearly defined in vivo. We …
sepsis, although the underlying mechanisms have not been clearly defined in vivo. We …
Translational implications of platelets as vascular first responders
RC Becker, T Sexton, SS Smyth - Circulation research, 2018 - Am Heart Assoc
Platelets play a vital role in normal hemostasis to stem blood loss at sites of vascular injury
by tethering and adhering to sites of injury, recruiting other platelets and blood cells to the …
by tethering and adhering to sites of injury, recruiting other platelets and blood cells to the …
Association of multiple biomarkers with risk of all-cause and cause-specific mortality after acute coronary syndromes: a secondary analysis of the PLATO biomarker …
Importance Mortality remains at about 5% within a year after an acute coronary syndrome
event. Prior studies have assessed biomarkers in relation to all-cause or cardiovascular …
event. Prior studies have assessed biomarkers in relation to all-cause or cardiovascular …
Effect of P2Y12 inhibitors on inflammation and immunity
Platelet P2Y 12 inhibitors form a major part of the treatment strategy for patients with acute
coronary syndromes (ACS) due to the importance of the platelet P2Y 12 receptor in …
coronary syndromes (ACS) due to the importance of the platelet P2Y 12 receptor in …
Management of patients on antithrombotic therapy with severe infections: a joint clinical consensus statement of the ESC Working Group on Thrombosis, the ESC …
Patients with severe infections and a pre-existing indication for antithrombotic therapy, ie
antiplatelet agents, anticoagulant drugs, or their combinations, require integrated clinical …
antiplatelet agents, anticoagulant drugs, or their combinations, require integrated clinical …
Balancing the risk of spontaneous ischemic and major bleeding events in acute coronary syndromes
Background Evaluation of antithrombotic treatments for acute coronary syndromes (ACS)
requires balancing ischemic and bleeding risks to assess net benefit. We sought to compare …
requires balancing ischemic and bleeding risks to assess net benefit. We sought to compare …
Comparison of clinical outcomes between ticagrelor and clopidogrel in East-Asian patients with acute coronary syndrome: large cohort study
WC Lee, CY Fang, YH Tsai, YY Hsieh, TY Chen… - American Journal of …, 2023 - Springer
Aim A high risk of bleeding is observed in East Asian patients with acute coronary syndrome
(ACS). Therefore, the choice between two antiplatelet therapy drugs, ticagrelor and …
(ACS). Therefore, the choice between two antiplatelet therapy drugs, ticagrelor and …