SARS-CoV-2 pathogenesis
MM Lamers, BL Haagmans - Nature reviews microbiology, 2022 - nature.com
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
caused a devastating pandemic. Although most people infected with SARS-CoV-2 develop …
caused a devastating pandemic. Although most people infected with SARS-CoV-2 develop …
Human organoids: model systems for human biology and medicine
The historical reliance of biological research on the use of animal models has sometimes
made it challenging to address questions that are specific to the understanding of human …
made it challenging to address questions that are specific to the understanding of human …
Engineering organoids
Organoids are in vitro miniaturized and simplified model systems of organs that have gained
enormous interest for modelling tissue development and disease, and for personalized …
enormous interest for modelling tissue development and disease, and for personalized …
Amplification-free detection of SARS-CoV-2 with CRISPR-Cas13a and mobile phone microscopy
The December 2019 outbreak of a novel respiratory virus, SARS-CoV-2, has become an
ongoing global pandemic due in part to the challenge of identifying symptomatic …
ongoing global pandemic due in part to the challenge of identifying symptomatic …
Human organoids in basic research and clinical applications
Organoids are three-dimensional (3D) miniature structures cultured in vitro produced from
either human pluripotent stem cells (hPSCs) or adult stem cells (AdSCs) derived from …
either human pluripotent stem cells (hPSCs) or adult stem cells (AdSCs) derived from …
A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics
The rapid repurposing of antivirals is particularly pressing during pandemics. However,
rapid assays for assessing candidate drugs typically involve in vitro screens and cell lines …
rapid assays for assessing candidate drugs typically involve in vitro screens and cell lines …
Infection of bat and human intestinal organoids by SARS-CoV-2
A novel coronavirus—severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)—
emerged in humans in Wuhan, China, in December 2019 and has since disseminated …
emerged in humans in Wuhan, China, in December 2019 and has since disseminated …
Progenitor identification and SARS-CoV-2 infection in human distal lung organoids
The distal lung contains terminal bronchioles and alveoli that facilitate gas exchange. Three-
dimensional in vitro human distal lung culture systems would strongly facilitate the …
dimensional in vitro human distal lung culture systems would strongly facilitate the …
SARS-CoV-2 Omicron variant is highly sensitive to molnupiravir, nirmatrelvir, and the combination
Dear Editor, Since the first outbreak in late 2019, the RNA genome of SARS-CoV-2 has
been undergoing constant evolution. This is largely attributed to the viral polymerase that is …
been undergoing constant evolution. This is largely attributed to the viral polymerase that is …
Human organoid models to study SARS-CoV-2 infection
Abstract Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) is one of the deadliest pandemics in history. SARS …
syndrome coronavirus 2 (SARS-CoV-2) is one of the deadliest pandemics in history. SARS …