Precise assembly of biomolecules into functional aggregate structures represents a key
characteristic of nature living cells, and is critical for the cellular processes. The construction …

G-quadruplexes are unusual DNA and RNA secondary structures ubiquitous in a variety of
organisms including vertebrates, plants, viruses and bacteria. The folding topology and …

The nature, composition, and topology of the active sites of both natural and artificial
enzymes are key determinants of their catalytic performance. While interesting structural …

While many protein enzymes exert their functions through multimerization, which improves
both selectivity and activity, this has not yet been demonstrated for other naturally occurring …

It is generally acknowledged that G-quadruplexes (G4s) acquire peroxidase activity upon
interaction with hemin. Hemin has been demonstrated to bind selectively to the 3′-terminal …

Catalytic DNA has gained significant attention in recent decades as a highly efficient and
tunable catalyst, thanks to its flexible structures, exceptional specificity, and ease of …

Oxidative damage of guanine to 8-oxoguanine triggers a partial and variable loss of G-
quadruplex/hemin DNAzyme activity and provides clues to the mechanistic origins of …

Aptamers can control the biological functions of enzymes, thereby facilitating the
development of novel biosensors. While aptamers that inhibit catalytic reactions of enzymes …

Catalysis using G‐quadruplexes (G‐4) has shown promise as a way to perform asymmetric
sulfoxidation of thioanisole derivatives. However, despite the relative simplicity of G‐4, the …

Two conjugation methods using different linkers were applied for the investigation of the
spectral characteristics and activity of G-quadruplex (G4)–hemin conjugates. For this …