Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials
Epigenetic alternations concern heritable yet reversible changes in histone or DNA
modifications that regulate gene activity beyond the underlying sequence. Epigenetic …
modifications that regulate gene activity beyond the underlying sequence. Epigenetic …
[HTML][HTML] Non-coding RNAs as regulators in epigenetics
Epigenetics is a discipline that studies heritable changes in gene expression that do not
involve altering the DNA sequence. Over the past decade, researchers have shown that …
involve altering the DNA sequence. Over the past decade, researchers have shown that …
Matrix metalloproteinases inhibitors in cancer treatment: an updated review (2013–2023)
Matrix metalloproteinases (MMPs) are identifiable members of proteolytic enzymes that can
degrade a wide range of proteins in the extracellular matrix (ECM). MMPs can be …
degrade a wide range of proteins in the extracellular matrix (ECM). MMPs can be …
[HTML][HTML] The roles of MicroRNA in lung cancer
Lung cancer is the most devastating malignancy in the world. Beyond genetic research,
epigenomic studies—especially investigations of microRNAs—have grown rapidly in …
epigenomic studies—especially investigations of microRNAs—have grown rapidly in …
Anti-inflammatory microRNAs and their potential for inflammatory diseases treatment
Inflammation is a complicated biological and pathophysiological cascade of responses to
infections and injuries, and inflammatory mechanisms are closely related to many diseases …
infections and injuries, and inflammatory mechanisms are closely related to many diseases …
MicroRNA as biomarkers and diagnostics
MicroRNAs (miRNAs) are a group of small non‐coding RNAs that are involved in regulating
a range of developmental and physiological processes; their dysregulation has been …
a range of developmental and physiological processes; their dysregulation has been …
The role of epigenetics in autoimmune/inflammatory disease
Historically, systemic self-inflammatory conditions were classified as either autoinflammatory
and caused by the innate immune system or autoimmune and driven by adaptive immune …
and caused by the innate immune system or autoimmune and driven by adaptive immune …
Micro-RNA: The darkhorse of cancer
The discovery of micro RNAs (miRNA) in cancer has opened up new vistas for researchers
in recent years. Micro RNAs area set of small, endogenous, highly conserved, non-coding …
in recent years. Micro RNAs area set of small, endogenous, highly conserved, non-coding …
MicroRNA (miRNA) in cancer
KB Reddy - Cancer cell international, 2015 - Springer
In recent years, there has been a tremendous and growing interest among researchers to
investigate the role of mircoRNA (miRNA) in normal cellular as well as in disease processes …
investigate the role of mircoRNA (miRNA) in normal cellular as well as in disease processes …
MicroRNAs and other non-coding RNAs as targets for anticancer drug development
The first cancer-targeted microRNA (miRNA) drug—MRX34, a liposome-based miR-34
mimic—entered Phase I clinical trials in patients with advanced hepatocellular carcinoma in …
mimic—entered Phase I clinical trials in patients with advanced hepatocellular carcinoma in …