Abdominal aortic aneurysm: update on pathogenesis and medical treatments

J Golledge - Nature Reviews Cardiology, 2019 - nature.com
Abdominal aortic aneurysm (AAA) rupture is an important cause of death in adults. Currently,
the only treatment for AAA is open or endovascular surgical repair. In most parts of the …

Monocytes and macrophages in abdominal aortic aneurysm

J Raffort, F Lareyre, M Clément… - Nature Reviews …, 2017 - nature.com
Abdominal aortic aneurysm (AAA) is a life-threatening disease associated with high
morbidity, and high mortality in the event of aortic rupture. Major advances in open surgical …

Understanding the pathogenesis of abdominal aortic aneurysms

H Kuivaniemi, EJ Ryer, JR Elmore… - Expert review of …, 2015 - Taylor & Francis
An aortic aneurysm is a dilatation in which the aortic diameter is≥ 3.0 cm. If left untreated,
the aortic wall continues to weaken and becomes unable to withstand the forces of the …

Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC Working Group on …

J van der Velden, FW Asselbergs… - Cardiovascular …, 2022 - academic.oup.com
Cardiovascular diseases represent a major cause of morbidity and mortality, necessitating
research to improve diagnostics, and to discover and test novel preventive and curative …

Pathogenesis-guided rational engineering of nanotherapies for the targeted treatment of abdominal aortic aneurysm by inhibiting neutrophilic inflammation

K Hu, L Zhong, W Lin, G Zhao, W Pu, Z Feng, M Zhou… - ACS …, 2024 - ACS Publications
Abdominal aortic aneurysm (AAA) remains a fatal disease in the elderly. Currently, no drugs
can be clinically used for AAA therapy. Considering the pivotal role of neutrophils in the …

IL-1β (interleukin-1β) and TNF-α (tumor necrosis factor-α) impact abdominal aortic aneurysm formation by differential effects on macrophage polarization

R Batra, MK Suh, JS Carson, MA Dale… - … and Vascular Biology, 2018 - ahajournals.org
Objective—Abdominal aortic aneurysms are inflammatory in nature and are associated with
some risk factors that also lead to atherosclerotic occlusive disease, most notably smoking …

Elastin-derived peptides promote abdominal aortic aneurysm formation by modulating M1/M2 macrophage polarization

MA Dale, W **ong, JS Carson, MK Suh… - The Journal of …, 2016 - journals.aai.org
Abdominal aortic aneurysm is a dynamic vascular disease characterized by inflammatory
cell invasion and extracellular matrix degradation. Damage to elastin in the extracellular …

Single-Cell RNA sequencing reveals heterogeneity of vascular cells in early stage murine abdominal aortic aneurysm—brief report

H Yang, T Zhou, A Stranz, E DeRoo… - … , thrombosis, and vascular …, 2021 - ahajournals.org
Objective: Abdominal aortic aneurysm (AAA) is a life-threatening vascular disease
characterized by smooth muscle cell depletion, ECM (extracellular matrix) degradation, and …

Purinergic receptor P2X7 contributes to abdominal aortic aneurysm development via modulating macrophage pyroptosis and inflammation

L Sun, X Li, Z Luo, M Li, H Liu, Z Zhu, J Wang, P Lu… - Translational …, 2023 - Elsevier
The purinergic receptor P2X7 has been established as an important mediator of
inflammation and participates in a variety of cardiovascular diseases including …

Tea polyphenol nanoparticles enable targeted siRNA delivery and multi-bioactive therapy for abdominal aortic aneurysms

Z Wu, P Zhang, J Yue, Q Wang, P Zhuang… - Journal of …, 2024 - Springer
Abdominal aortic aneurysm (AAA) is a life-threatening vascular disease, while there is a lack
of pharmaceutical interventions to halt AAA progression presently. To address the …