The transient receptor potential (TRP) superfamily of channels comprises a diverse group of
cation channels. Four TRP channel subunits coassemble to form functional homo-or …

Primary ciliary dyskinesia (PCD) is usually inherited as an autosomal recessive disorder and
presents with upper and lower respiratory tract infection, and mirror image arrangement in …

Cilia and flagella are widespread cell organelles that have been highly conserved
throughout evolution and play important roles in motility, sensory perception, and the life …

Polycystic kidney disease (PKD) is a common human genetic illness. It is characterized by
the formation of multiple kidney cysts that are thought to result from over-proliferation of …

Mutations in the polycystin genes, PKD1 or PKD2, results in Autosomal Dominant Polycystic
Kidney Disease (ADPKD). Although a genetic basis of ADPKD is established, we lack a …

The primary cilium is an antenna-like structure that protrudes from the cell surface of
quiescent/differentiated cells and participates in extracellular signal processing,,. Here, we …

The primary cilium has evolved as a multifunctional cellular compartment that decorates
most vertebrate cells. Cilia sense mechanical stimuli in various organs, but the molecular …

Although human pathologies have mostly been modeled using higher mammal systems
such as mice, the lower vertebrate zebrafish has gained tremendous attention as a model …

This review aims to assist in the categorization of inherited, developmental, and acquired
cystic disease of the kidney as well as to provide a pertinent, up-to-date bibliography. The …

Wwtr1 is a widely expressed 14-3-3-binding protein that regulates the activity of several
transcription factors involved in development and disease. To elucidate the physiological …