In humans, the thyroid hormones T3 and T4 are synthesized in the thyroid gland in a
process that crucially involves the iodoglycoprotein thyroglobulin. The overall structure of …

Iodine is a micronutrient needed for the production of thyroid hormones, which regulate
metabolism, growth, and development. Iodine deficiency or excess may alter the thyroid …

Simple Summary Tumor biomarkers are molecules at genetic or protein level, or certain
evaluable characteristics. These help in perfecting patient management. Over the past …

Congenital hypothyroidism (CH) may be primary, due to a defect affecting the thyroid gland
itself, or central, due to impaired thyroid-stimulating hormone (TSH)-mediated stimulation of …

Thyroid hormones and iodine are required to increase basal metabolic rate and to regulate
protein synthesis, long bone growth and neuronal maturation. They are also essential for …

The sodium iodide symporter (NIS) is an intrinsic plasma membrane protein that mediates
active iodide transport into the thyroid gland and into several extrathyroidal tissues. NIS …

Krüppel-like zinc finger proteins form one of the largest families of transcription factors. They
function as key regulators of embryonic development and a wide range of other …

Background: Hyalinizing trabecular tumor (HTT) is a rare thyroid neoplasm with a
characteristic trabecular growth pattern and hyalinization. This lesion has been the subject …

Context Congenital hypothyroidism (CH) is the most common endocrine disorder in
neonates, but its etiology is still poorly understood. Objective We performed whole exome …

ABSTRACT GLI-Similar 3 (GLIS3) is a member of the GLIS subfamily of Krüppel-like zinc
finger transcription factors that functions as an activator or repressor of gene expression …