Early Alzheimer's disease pathology in human cortex involves transient cell states
Cellular perturbations underlying Alzheimer's disease (AD) are primarily studied in human
postmortem samples and model organisms. Here, we generated a single-nucleus atlas from …
postmortem samples and model organisms. Here, we generated a single-nucleus atlas from …
On the functions, mechanisms, and malfunctions of intracortical contextual modulation
A broad neuron-centric conception of contextual modulation is reviewed and re-assessed in
the light of recent neurobiological studies of amplification, suppression, and synchronization …
the light of recent neurobiological studies of amplification, suppression, and synchronization …
[HTML][HTML] Distinctive biophysical features of human cell-types: insights from studies of neurosurgically resected brain tissue
HM Chameh, M Falby, M Movahed, K Arbabi… - Frontiers in Synaptic …, 2023 - frontiersin.org
Electrophysiological characterization of live human tissue from epilepsy patients has been
performed for many decades. Although initially these studies sought to understand the …
performed for many decades. Although initially these studies sought to understand the …
Trace fear conditioning differentially modulates intrinsic excitability of medial prefrontal cortex–basolateral complex of amygdala projection neurons in infralimbic and …
Neuronal activity in medial prefrontal cortex (mPFC) is critical for the formation of trace fear
memory, yet the cellular mechanisms underlying these memories remain unclear. One …
memory, yet the cellular mechanisms underlying these memories remain unclear. One …
D3 receptors regulate excitability in a unique class of prefrontal pyramidal cells
RL Clarkson, AT Liptak, SM Gee, VS Sohal… - Journal of …, 2017 - Soc Neuroscience
The D3 dopamine receptor, a member of the Gi-coupled D2 family of dopamine receptors, is
expressed throughout limbic circuits affected in neuropsychiatric disorders, including …
expressed throughout limbic circuits affected in neuropsychiatric disorders, including …
Cortical output is gated by horizontally projecting neurons in the deep layers
Pyramidal tract neurons (PTs) represent the major output cell type of the mammalian
neocortex. Here, we report the origins of the PTs' ability to respond to a broad range of …
neocortex. Here, we report the origins of the PTs' ability to respond to a broad range of …
Adrenergic modulation regulates the dendritic excitability of layer 5 pyramidal neurons in vivo
The excitability of the apical tuft of layer 5 pyramidal neurons is thought to play a crucial role
in behavioral performance and synaptic plasticity. We show that the excitability of the apical …
in behavioral performance and synaptic plasticity. We show that the excitability of the apical …
High-frequency burst spiking in layer 5 thick-tufted pyramids of rat primary somatosensory cortex encodes exploratory touch
Diversity of cell-types that collectively shape the cortical microcircuit ensures the necessary
computational richness to orchestrate a wide variety of behaviors. The information content …
computational richness to orchestrate a wide variety of behaviors. The information content …
Two forms of synaptic depression produced by differential neuromodulation of presynaptic calcium channels
Neuromodulators are important regulators of synaptic transmission throughout the brain. At
the presynaptic terminal, neuromodulation of calcium channels (CaVs) can affect …
the presynaptic terminal, neuromodulation of calcium channels (CaVs) can affect …
Cognitive functions of intracellular mechanisms for contextual amplification
WA Phillips - Brain and Cognition, 2017 - Elsevier
Evidence for the hypothesis that input to the apical tufts of neocortical pyramidal cells plays a
central role in cognition by amplifying their responses to feedforward input is reviewed …
central role in cognition by amplifying their responses to feedforward input is reviewed …