Navigating environmental transitions: the role of phenotypic variation in bacterial responses

MR Spratt, K Lane - Mbio, 2022 - Am Soc Microbiol
The ability of bacteria to respond to changes in their environment is critical to their survival,
allowing them to withstand stress, form complex communities, and induce virulence …

Observation of universal ageing dynamics in antibiotic persistence

Y Kaplan, S Reich, E Oster, S Maoz, I Levin-Reisman… - Nature, 2021 - nature.com
Stress responses allow cells to adapt to changes in external conditions by activating specific
pathways. Here we investigate the dynamics of single cells that were subjected to acute …

Microbial effects on plant phenology and fitness

AM O'Brien, NA Ginnan… - American journal of …, 2021 - Wiley Online Library
Plant development and the timing of developmental events (phenology) are tightly coupled
with plant fitness. A variety of internal and external factors determine the timing and fitness …

Suboptimal resource allocation in changing environments constrains response and growth in bacteria

R Balakrishnan, RT de Silva, T Hwa… - Molecular systems …, 2021 - embopress.org
To respond to fluctuating conditions, microbes typically need to synthesize novel proteins.
As this synthesis relies on sufficient biosynthetic precursors, microbes must devise effective …

Minorities drive growth resumption in cross-feeding microbial communities

G Micali, AM Hockenberry, A Dal Co… - Proceedings of the …, 2023 - National Acad Sciences
Microbial communities are fundamental to life on Earth. Different strains within these
communities are often connected by a highly connected metabolic network, where the …

Phenotypic heterogeneity follows a growth-viability tradeoff in response to amino acid identity

K Shabestary, C Klemm, B Carling, J Marshall… - Nature …, 2024 - nature.com
In their natural environments, microorganisms mainly operate at suboptimal growth
conditions with fluctuations in nutrient abundance. The resulting cellular adaptation is …

Community interactions drive the evolution of antibiotic tolerance in bacteria

S Pearl Mizrahi, A Goyal, J Gore - Proceedings of the …, 2023 - National Acad Sciences
The emergence of antibiotic tolerance (prolonged survival against exposure) in natural
bacterial populations is a major concern. Since it has been studied primarily in isogenic …

Harnessing plant-microbiome interactions for bioremediation across a freshwater urbanization gradient

AM O'Brien, ZH Yu, C Pencer, ME Frederickson… - Water Research, 2022 - Elsevier
Urbanization impacts land, air, and water, creating environmental gradients between cities
and rural areas. Urban stormwater delivers myriad co-occurring, understudied, and mostly …

[HTML][HTML] Fragmented micro-growth habitats present opportunities for alternative competitive outcomes

M Batsch, I Guex, H Todorov, CM Heiman… - Nature …, 2024 - nature.com
Bacteria in nature often thrive in fragmented environments, like soil pores, plant roots or
plant leaves, leading to smaller isolated habitats, shared with fewer species. This spatial …

Tradeoff between lag time and growth rate drives the plasmid acquisition cost

M Ahmad, H Prensky, J Balestrieri, S ElNaggar… - Nature …, 2023 - nature.com
Conjugative plasmids drive genetic diversity and evolution in microbial populations. Despite
their prevalence, plasmids can impose long-term fitness costs on their hosts, altering …