Products of the LMNA gene, primarily lamin A and C, are key components of the nuclear
lamina, a proteinaceous meshwork that underlies the inner nuclear membrane and is …

The genome is packaged and organized nonrandomly within the 3D space of the nucleus to
promote efficient gene expression and to faithfully maintain silencing of heterochromatin …

Premature aging disorders provide an opportunity to study the mechanisms that drive aging.
In Hutchinson-Gilford progeria syndrome (HGPS), a mutant form of the nuclear scaffold …

Lamins are components of the peripheral nuclear lamina and interact with heterochromatic
genomic regions, termed lamina-associated domains (LADs). In contrast to lamin B1 being …

Nuclear lamins are components of the peripheral lamina that define the mechanical
properties of nuclei and tether heterochromatin to the periphery. A-type lamins localize also …

Telomeres are dynamic nucleoprotein-DNA structures that cap and protect linear
chromosome ends. Several monogenic inherited diseases that display features of human …

The nuclear envelope (NE) is the central organizing unit of the eukaryotic cell serving as a
genome protective barrier and mechanotransduction interface between the cytoplasm and …

Hutchinson–Gilford progeria syndrome (HGPS) is an extremely rare premature aging
disease presenting many features resembling the normal aging process. HGPS patients die …

Senescence is the end point of a complex cellular response that proceeds through a set of
highly regulated steps. Initially, the permanent cell-cycle arrest that characterizes …

The nuclear lamina (NL) is a structural component of the nuclear envelope and makes
extensive contacts with integral nuclear membrane proteins and chromatin. These …