Intrinsic disorder is a natural feature of polypeptide chains, resulting in the lack of a defined
three-dimensional structure. Conformational changes in intrinsically disordered regions of a …

Prions, which cause fatal neurodegenerative disorders such as Creutzfeldt‐Jakob disease,
are misfolded and infectious protein aggregates. Currently, there are no treatments available …

TDP-43, or TAR DNA-binding protein 43, is a pathological marker of a spectrum of
neurodegenerative disorders, including amyotrophic lateral sclerosis and frontotemporal …

Exosomes are small extracellular vesicles released by cells and play important roles in
intercellular communication and pathogen transfer. Exosomes have been implicated in …

Exosomes are small membrane‐bound vesicles released from cells and found in vivo in
most biological fluids. Functions reported for exosomes include cell–cell communication …

While it might be expected that fidelity is always perfect in map** from the DNA triple code
to the specific amino acid it codes for, multiple studies have shown that this is not the case [1 …

The study of prions as infectious aggregates dates several decades. From its original
formulation, the definition of a prion has progressively changed to the point that many …

Most neurodegenerative diseases have the characteristics of protein folding disorders, ie,
they cause lesions to appear in vulnerable regions of the nervous system, corresponding to …

Simple Summary Despite its involvement in several human pathophysiological processes,
the cellular prion protein (PrPC) remains enigmatic. During the last ten years, PrPC has also …

TGF-β is considered a master switch in the pathogenesis of organ fibrosis. The primary
mediators of this activity are the SMAD proteins, particularly SMAD3. In the current study, we …