Less than a decade ago, it was shown that bromodomains, acetyl lysine 'reader'modules
found in proteins with varied functions, were highly tractable small-molecule targets. This is …

The histone acetyltransferases CBP and p300, often referred to as CBP/p300 due to their
sequence homology and functional overlap and co-operation, are emerging as critical …

CCS1477 (inobrodib) is a potent, selective EP300/CBP bromodomain inhibitor which
induces cell-cycle arrest and differentiation in hematologic malignancy model systems. In …

CBP/p300, functioning as histone acetyltransferases and transcriptional co-factors,
represents an attractive target for various diseases, including malignant tumor. The …

Aims: Lipid peroxidation occurring in lung adenocarcinoma (LUAD) cells leads to
ferroptosis. Lysophosphatidylcholine acyl-transferase 3 (LPCAT3) plays a key role in …

Cellular reprogramming by only small molecules holds enormous potentials for regenerative
medicine. However, chemical reprogramming remains a slow process and labour intensive …

Epithelial-mesenchymal transition (EMT) and its critical roles during cancer progression
have long been recognized and extensively reviewed. Recent studies on the generation of …

Ferroptosis is a new form of regulated cell death and closely related to cancer. However, the
mechanism underlying the regulation of ferroptosis in lung adenocarcinoma (LUAD) …

The metazoan-specific acetyltransferase p300/CBP is involved in activating signal-induced,
enhancer-mediated transcription of cell-type-specific genes. However, the global kinetics …

Fibrotic diseases remain a major cause of morbidity and mortality, yet there are few effective
therapies. The underlying pathology of all fibrotic conditions is the activity of myofibroblasts …