The rise of personalised and highly complex drug product profiles necessitates significant
advancements in pharmaceutical manufacturing and distribution. Efforts to develop more …

Highlights•GAMP 5 meets industry and regulatory expectations for the validation of IT
systems.•Data integrity ensures accurate, reliable data for informed decisions in drug …

The article aims to propose a comprehensive approach to sustainable practices and risk
resilience in a circular economy within the supply chain of a manufacturing company …

This paper reviews literature that addresses applications of resilience engineering principles
to various fields. Recently the concept has attracted great attention from a technical and …

The implementation of continuous pharmaceutical manufacturing requires advanced control
strategies rather than traditional end product testing or an operation within a small range of …

Smart manufacturing (SM) enables production scheduling to automatically adjust the
original plan to meet customer demands. The deep integration of advanced information …

Data provided by in situ sensors is always affected by some level of impreciseness as well
as uncertainty in the measurements due to process operation disturbance or material …

In this paper we present a framework to design control systems for an evaporation process
in the pharmaceutical industry with the aim to deliver guaranteed operability for different …

This paper outlines several control strategies for a feeding blending unit in a continuous
pharmaceutical manufacturing setup, with the goal of dam** feeder fluctuations by …

The fluctuation of various parameters in the production process increases the risk of
generating unqualified products and suffering from systematic failures and downtimes, and …