[HTML][HTML] Antibodies from primary humoral responses modulate the recruitment of naive B cells during secondary responses
Vaccines generate high-affinity antibodies by recruiting antigen-specific B cells to germinal
centers (GCs), but the mechanisms governing the recruitment to GCs on secondary …
centers (GCs), but the mechanisms governing the recruitment to GCs on secondary …
Targeted isolation of diverse human protective broadly neutralizing antibodies against SARS-like viruses
The emergence of current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
variants of concern (VOCs) and potential future spillovers of SARS-like coronaviruses into …
variants of concern (VOCs) and potential future spillovers of SARS-like coronaviruses into …
[HTML][HTML] A human antibody epitope map of Pfs230D1 derived from analysis of individuals vaccinated with a malaria transmission-blocking vaccine
WK Tang, CH Coelho, K Miura, BCN Tentokam… - Immunity, 2023 - cell.com
Summary Pfs230 domain 1 (Pfs230D1) is an advanced malaria transmission-blocking
vaccine antigen demonstrating high functional activity in clinical trials. However, the …
vaccine antigen demonstrating high functional activity in clinical trials. However, the …
Enhancing antibody responses by multivalent antigen display on thymus-independent DNA origami scaffolds
Protein-based virus-like particles (P-VLPs) are commonly used to spatially organize
antigens and enhance humoral immunity through multivalent antigen display. However, P …
antigens and enhance humoral immunity through multivalent antigen display. However, P …
Use of 3M-052-AF with alum adjuvant in HIV trimer vaccine induces human autologous neutralizing antibodies
WO Hahn, KR Parks, M Shen, G Ozorowski… - Journal of Experimental …, 2024 - rupress.org
Stabilized trimers preserving the native-like HIV envelope structure may be key components
of a preventive HIV vaccine regimen to induce broadly neutralizing antibodies (bnAbs). We …
of a preventive HIV vaccine regimen to induce broadly neutralizing antibodies (bnAbs). We …
Rethinking Optimal Immunogens to Face SARS‐CoV‐2 Evolution Through Vaccination
ABSTRACT SARS‐CoV‐2, which originated in China in late 2019, quickly fueled the global
COVID‐19 pandemic, profoundly impacting health and the economy worldwide. A series of …
COVID‐19 pandemic, profoundly impacting health and the economy worldwide. A series of …
Carbohydrate fatty acid monosulphate: oil-in-water adjuvant enhances SARS-CoV-2 RBD nanoparticle-induced immunogenicity and protection in mice
Abstract Development of SARS-CoV-2 vaccines that protect vulnerable populations is a
public health priority. Here, we took a systematic and iterative approach by testing several …
public health priority. Here, we took a systematic and iterative approach by testing several …
Adaptation‐Proof SARS‐CoV‐2 Vaccine Design
YL Vishweshwaraiah, B Hnath… - Advanced functional …, 2022 - Wiley Online Library
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) surface spike glycoprotein—
a major antibody target—is critical for virus entry via engagement of human angiotensin …
a major antibody target—is critical for virus entry via engagement of human angiotensin …
Cross-reactive SARS-CoV-2 epitope targeted across donors informs immunogen design
The emergence of the antigenically distinct and highly transmissible Omicron variant
highlights the possibility of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …
highlights the possibility of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …
Engineering a SARS-CoV-2 Vaccine Targeting the Receptor-Binding Domain Cryptic-Face via Immunofocusing
The receptor-binding domain (RBD) of the SARS-CoV-2 spike protein is the main target of
neutralizing antibodies. Although they are infrequently elicited during infection or …
neutralizing antibodies. Although they are infrequently elicited during infection or …