Organic azides: an exploding diversity of a unique class of compounds
S Bräse, C Gil, K Knepper… - Angewandte Chemie …, 2005 - Wiley Online Library
Since the discovery of organic azides by Peter Grieß more than 140 years ago, numerous
syntheses of these energy‐rich molecules have been developed. In more recent times in …
syntheses of these energy‐rich molecules have been developed. In more recent times in …
Synthesis of DNA-Interactive Pyrrolo[2,1-c][1,4]benzodiazepines (PBDs)
D Antonow, DE Thurston - Chemical reviews, 2011 - ACS Publications
1.1. General Background Discovered in the 1960s, 1 the pyrrolobenzodiazepines (PBDs)
are an important class of sequence-selective DNA-interactive agents that bind covalently to …
are an important class of sequence-selective DNA-interactive agents that bind covalently to …
Palladium-Catalyzed Oxidative C–H Bond Coupling of Steered Acetanilides and Aldehydes: A Facile Access to ortho-Acylacetanilides
Y Wu, B Li, F Mao, X Li, FY Kwong - Organic Letters, 2011 - ACS Publications
A palladium-catalyzed oxidative C–H bond functionalization/ortho-acylation of acetanilides
using easily accessible aldehyde as the acyl source is described. In the presence of a Pd …
using easily accessible aldehyde as the acyl source is described. In the presence of a Pd …
Design, synthesis, and evaluation of new noncross-linking pyrrolobenzodiazepine dimers with efficient DNA binding ability and potent antitumor activity
A Kamal, G Ramesh, N Laxman… - Journal of medicinal …, 2002 - ACS Publications
New sequence selective mixed imine-amide pyrrolobenzodiazepine (PBD) dimers have
been developed that are comprised of DC-81 and dilactam of DC-81 subunits tethered to …
been developed that are comprised of DC-81 and dilactam of DC-81 subunits tethered to …
Quinazolinone linked pyrrolo [2, 1-c][1, 4] benzodiazepine (PBD) conjugates: Design, synthesis and biological evaluation as potential anticancer agents
A series of novel quinazolinone linked pyrrolobenzodiazepine (PBD) conjugates were
synthesized. These compounds 4a–f and 5a–f were prepared in good yields by linking C-8 …
synthesized. These compounds 4a–f and 5a–f were prepared in good yields by linking C-8 …
Organische Azide–explodierende Vielfalt bei einer einzigartigen Substanzklasse
S Bräse, C Gil, K Knepper… - Angewandte Chemie, 2005 - Wiley Online Library
Seit der Entdeckung der organischen Azide vor über einhundertvierzig Jahren durch Peter
Grieß wurde eine Reihe von Synthesen für diese energiereichen Moleküle entwickelt. In …
Grieß wurde eine Reihe von Synthesen für diese energiereichen Moleküle entwickelt. In …
Design, synthesis and biological evaluation of 3, 5-diaryl-isoxazoline/isoxazole-pyrrolobenzodiazepine conjugates as potential anticancer agents
A series of 3, 5-diaryl-isoxazoline/isoxazole linked pyrrolo [2, 1-c][1, 4] benzodiazepine
(PBD) conjugates were prepared. These conjugates showed potent anticancer activity with …
(PBD) conjugates were prepared. These conjugates showed potent anticancer activity with …
Mild and efficient reduction of azides to amines: synthesis of fused [2, 1-b] quinazolinones
A Kamal, KV Ramana, HB Ankati, AV Ramana - Tetrahedron letters, 2002 - Elsevier
Mild and efficient reduction of azides to amines: synthesis of fused [2,1-b]quinazolinones -
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Diels−Alder Reaction−Aromatization Approach toward Functionalized Ring C Allocolchicinoids. Enantioselective Total Synthesis of (−)-7S-Allocolchicine
AV Vorogushin, AV Predeus, WD Wulff… - The Journal of Organic …, 2003 - ACS Publications
Allocolchicinoids are analogues of the important antimitotic compound (−)-colchicine 1. A
strategy is reported for the synthesis of ring C functionalized allocolchicinoids, which is …
strategy is reported for the synthesis of ring C functionalized allocolchicinoids, which is …
Recent developments in the design, synthesis and structure-activity relationship studies of pyrrolo [2, 1-c][1, 4] benzodiazepines as DNA-interactive antitumour …
A Kamal, MV Rao, N Laxman… - … -Anti-Cancer Agents, 2002 - ingentaconnect.com
Pyrrolo [2, 1-c][1, 4] benzodiazepines (PBDs) are naturally occurring compounds isolated
from various Streptomyces species. The PBDs exert their biological activity through covalent …
from various Streptomyces species. The PBDs exert their biological activity through covalent …