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GABAkines–Advances in the discovery, development, and commercialization of positive allosteric modulators of GABAA receptors
Positive allosteric modulators of γ-aminobutyric acid-A (GABA A) receptors or GABAkines
have been widely used medicines for over 70 years for anxiety, epilepsy, sleep, and other …
have been widely used medicines for over 70 years for anxiety, epilepsy, sleep, and other …
Reactive metabolites of the anticonvulsant drugs and approaches to minimize the adverse drug reaction
Several generations of antiepileptic drugs (AEDs) are available in the market for the
treatment of seizures, but these are amalgamated with acute to chronic side effects. The …
treatment of seizures, but these are amalgamated with acute to chronic side effects. The …
Neuropharmacological and Antidiabetic Potential of Lannea coromandelica (Houtt.) Merr. Leaves Extract: An Experimental Analysis
The present study examines the neuropharmacological and antidiabetic properties of
methanol leaves extract of Lannea coromandelica in animal models. This study is carried …
methanol leaves extract of Lannea coromandelica in animal models. This study is carried …
[HTML][HTML] Citrus limon L.(lemon) seed extract shows neuro-modulatory activity in an in vivo thiopental-sodium sleep model by reducing the sleep onset and enhancing …
Citrus limon L. is an ingenious alternative medication and has a broad scope in managing
several health conditions as part of natural remedies. Recently, medicinal plants have …
several health conditions as part of natural remedies. Recently, medicinal plants have …
3, 5-Disubstituted-thiazolidine-2, 4-dione hybrids as antidiabetic agents: Design, synthesis, in-vitro and In vivo evaluation
Diabetes is one of the fastest-growing metabolic disorders, nearly doubling the number of
patients each year. There are different treatment approaches available for the management …
patients each year. There are different treatment approaches available for the management …
Recent Advances in Transition‐Metal‐Catalyzed Oxidative Annulations to Benzazepines and Benzodiazepines
Á Velasco‐Rubio, JA Varela… - Advanced Synthesis & …, 2020 - Wiley Online Library
Benzazepines and benzodiazepines, benzofused seven‐membered N‐heterocycles,
compose an important family of natural products and pharmaceuticals. Although certainly …
compose an important family of natural products and pharmaceuticals. Although certainly …
A study on synthesis of benzodiazepine scaffolds using biologically active chalcones as precursors
Nowadays, heterocyclic compounds have attained a prominent place among the numerous
classes of aromatic organic compounds in medicinal chemistry due to their important …
classes of aromatic organic compounds in medicinal chemistry due to their important …
[HTML][HTML] Effect of alpha-mangostin in the prevention of behavioural and neurochemical defects in methylmercury-induced neurotoxicity in experimental rats
Methylmercury (MeHg+) is a known neurotoxin that causes progressive motor neuron
degeneration in the central nervous system. Axonal degeneration, oligodendrocyte …
degeneration in the central nervous system. Axonal degeneration, oligodendrocyte …
Discovery of thiazolidinedione-based pancreatic lipase inhibitors as anti-obesity agents: synthesis, in silico studies and pharmacological investigations
Abstract A series of new 2, 5-disubstituted arylidene derivatives of thiazolidinedione (16a-e,
17a-d, 18a-c) designed using molecular hybridization approach were synthesized …
17a-d, 18a-c) designed using molecular hybridization approach were synthesized …
Design, Synthesis, In Vivo, and In Silico Evaluation of Benzothiazoles Bearing a 1,3,4-Oxadiazole Moiety as New Antiepileptic Agents
In the presented manuscript, a new series of 2-[4-methoxy-3-(5-substituted phenyl-[1, 3, 4]
oxadiazol-2-ylmethoxy)-phenyl]-benzothiazoles (6a–n) have been synthesized and studied …
oxadiazol-2-ylmethoxy)-phenyl]-benzothiazoles (6a–n) have been synthesized and studied …