GABAkines–Advances in the discovery, development, and commercialization of positive allosteric modulators of GABAA receptors

A Lippa, MM Poe, JL Smith, X **, X **… - Pharmacology & …, 2022 - Elsevier
Positive allosteric modulators of γ-aminobutyric acid-A (GABA A) receptors or GABAkines
have been widely used medicines for over 70 years for anxiety, epilepsy, sleep, and other …

Reactive metabolites of the anticonvulsant drugs and approaches to minimize the adverse drug reaction

R Pal, K Singh, SA Khan, P Chawla, B Kumar… - European Journal of …, 2021 - Elsevier
Several generations of antiepileptic drugs (AEDs) are available in the market for the
treatment of seizures, but these are amalgamated with acute to chronic side effects. The …

Neuropharmacological and Antidiabetic Potential of Lannea coromandelica (Houtt.) Merr. Leaves Extract: An Experimental Analysis

F Islam, S Mitra, MH Nafady… - Evidence‐Based …, 2022 - Wiley Online Library
The present study examines the neuropharmacological and antidiabetic properties of
methanol leaves extract of Lannea coromandelica in animal models. This study is carried …

[HTML][HTML] Citrus limon L.(lemon) seed extract shows neuro-modulatory activity in an in vivo thiopental-sodium sleep model by reducing the sleep onset and enhancing …

MM Rahman, F Islam, A Parvez, MAK Azad… - Journal of Integrative …, 2022 - imrpress.com
Citrus limon L. is an ingenious alternative medication and has a broad scope in managing
several health conditions as part of natural remedies. Recently, medicinal plants have …

3, 5-Disubstituted-thiazolidine-2, 4-dione hybrids as antidiabetic agents: Design, synthesis, in-vitro and In vivo evaluation

G Singh, R Singh, V Monga, S Mehan - European Journal of Medicinal …, 2024 - Elsevier
Diabetes is one of the fastest-growing metabolic disorders, nearly doubling the number of
patients each year. There are different treatment approaches available for the management …

Recent Advances in Transition‐Metal‐Catalyzed Oxidative Annulations to Benzazepines and Benzodiazepines

Á Velasco‐Rubio, JA Varela… - Advanced Synthesis & …, 2020 - Wiley Online Library
Benzazepines and benzodiazepines, benzofused seven‐membered N‐heterocycles,
compose an important family of natural products and pharmaceuticals. Although certainly …

A study on synthesis of benzodiazepine scaffolds using biologically active chalcones as precursors

AS Bhathiwal, A Bendi, A Tiwari - Journal of Molecular Structure, 2022 - Elsevier
Nowadays, heterocyclic compounds have attained a prominent place among the numerous
classes of aromatic organic compounds in medicinal chemistry due to their important …

[HTML][HTML] Effect of alpha-mangostin in the prevention of behavioural and neurochemical defects in methylmercury-induced neurotoxicity in experimental rats

R Sahu, S Mehan, S Kumar, A Prajapati… - Toxicology Reports, 2022 - Elsevier
Methylmercury (MeHg+) is a known neurotoxin that causes progressive motor neuron
degeneration in the central nervous system. Axonal degeneration, oligodendrocyte …

Discovery of thiazolidinedione-based pancreatic lipase inhibitors as anti-obesity agents: synthesis, in silico studies and pharmacological investigations

P Dhiman, N Yadav, PS Auti, S Jaswal… - Journal of …, 2024 - Taylor & Francis
Abstract A series of new 2, 5-disubstituted arylidene derivatives of thiazolidinedione (16a-e,
17a-d, 18a-c) designed using molecular hybridization approach were synthesized …

Design, Synthesis, In Vivo, and In Silico Evaluation of Benzothiazoles Bearing a 1,3,4-Oxadiazole Moiety as New Antiepileptic Agents

B Chauhan, R Kumar, Salahuddin, H Singh, O Afzal… - ACS …, 2023 - ACS Publications
In the presented manuscript, a new series of 2-[4-methoxy-3-(5-substituted phenyl-[1, 3, 4]
oxadiazol-2-ylmethoxy)-phenyl]-benzothiazoles (6a–n) have been synthesized and studied …