Platelets are anucleate cytoplasmic fragments derived from the fragmentation of medullary
megakaryocytes. Activated platelets adhere to the damaged endothelium by means of …

Debate on appropriate triggers for transfusion of allogeneic blood products and their effects
on short-and long-term survival in surgical and critically ill patients continue with no …

Platelets can be considered sentinels of vascular system due to their high number in the
circulation and to the range of functional immunoreceptors they express. Platelets express a …

Platelet concentrate (PC) transfusions are a lifesaving adjunct to control and prevent
bleeding in cancer, hematologic, surgical, and trauma patients. Platelet concentrate …

The search for alternatives to the use of fetal bovine serum (FBS) in cell and tissue culture
media has become a major goal in terms of the 3R principles in order to reduce or to avoid …

The CD40 ligand (CD40L) is a transmembrane molecule of crucial interest in cell signaling
in innate and adaptive immunity. It is expressed by a variety of cells, but mainly by activated …

Blood platelets play a central hemostatic role,(i) as they repair vascular epithelial damage,
and (ii) they play immune defense roles, as they have the capacity to produce and secrete …

While platelet function has traditionally been described in the context of maintaining
vascular integrity, recent evidence suggests that platelets can modulate inflammation in a …

Hypothesis Transfusion of fresh frozen plasma (FFP) and platelets is independently
associated with the development of multiple organ failure (MOF) in critically injured patients …

Resuscitation of children and neonates with severe or refractory bleeding due to surgery or
trauma often requires massive transfusion (MT). Findings from recent studies have led to a …