Abstract The Sequence Alignment/Map (SAM) format file is the text file used to record
alignment information. Alignment is the core of sequencing analysis, and downstream tasks …

As the cost of sequencing continues to decrease and the amount of sequence data
generated grows, new paradigms for data storage and analysis are increasingly important …

Recently, there has been growing interest in genome sequencing, driven by advances in
sequencing technology, in terms of both efficiency and affordability. These developments …

Background Microbial inhabitants of soils are important to ecosystem and planetary
functions, yet there are large gaps in our knowledge of their diversity and ecology. The …

During software development it is helpful to obtain early estimates of the defect density of
software components. Such estimates identify fault-prone areas of code requiring further …

Current DNA storage schemes lack flexibility and consistency in processing highly
redundant and correlated image data, resulting in low sequence stability and image …

The ever increasing growth of the production of high-throughput sequencing data poses a
serious challenge to the storage, processing and transmission of these data. As frequently …

Why should we start a book on bioinformatics with BLAST (Altschul et al. 1990) and FASTA
(Lipman and Pearson 1985; Pearson 1990; Pearson and Lipman 1988)? There surely were …

Research on protein–protein interactions (PPIs) not only helps to reveal the nature of life
activities but also plays a driving role in understanding the mechanisms of disease activity …

Comprehensive collections approaching millions of sequenced genomes have become
central information sources in the life sciences. However, the rapid growth of these …