There are still many unanswered questions concerning viral SARS-CoV-2 pathogenesis in
COVID-19. Accessory proteins in SARS-CoV-2 consist of eleven viral proteins whose roles …

In December 2019, an outbreak of pneumonia of unknown origin was reported in Wuhan,
Hubei Province, China. Pneumonia cases were epidemiologically linked to the Huanan …

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has caused the ongoing
pandemic of Coronavirus Disease 2019. SARS-CoV-2 belongs to the genus …

Autophagy acts as a cellular surveillance mechanism to combat invading pathogens.
Viruses have evolved various strategies to block autophagy and even subvert it for their …

Severe acute respiratory syndrome coronavirus (SARS-CoV) is capable of inducing a storm
of proinflammatory cytokines. In this study, we show that the SARS-CoV open reading frame …

Nod-like receptor family, pyrin domain-containing 3 (NLRP3) regulates the secretion of
proinflammatory cytokines interleukin 1 beta (IL-1β) and IL-18. We previously showed that …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread in
humans in almost every country, causing the disease COVID-19. Since the start of the …

The ongoing SARS-CoV-2 pandemic has shocked the world due to its persistence, COVID-
19-related morbidity and mortality, and the high mutability of the virus. One of the major …

Abstract SARS-CoV-2 ORF3a is a putative viral ion channel implicated in autophagy
inhibition, inflammasome activation and apoptosis. 3a protein and anti-3a antibodies are …

SARS-CoV-2 might directly activate NLRP3 inflammasome resulting in an endogenous
adjuvant activity necessary to mount a proper adaptive immune response against the virus …