Phage therapy in the postantibiotic era

FL Gordillo Altamirano, JJ Barr - Clinical microbiology reviews, 2019 - Am Soc Microbiol
Antibiotic resistance is arguably the biggest current threat to global health. An increasing
number of infections are becoming harder or almost impossible to treat, carrying high …

Phages for phage therapy: isolation, characterization, and host range breadth

P Hyman - Pharmaceuticals, 2019 - mdpi.com
For a bacteriophage to be useful for phage therapy it must be both isolated from the
environment and shown to have certain characteristics beyond just killing strains of the …

[HTML][HTML] Phage therapy in the resistance era: where do we stand and where are we going?

T Luong, AC Salabarria, DR Roach - Clinical therapeutics, 2020 - Elsevier
Purpose Widespread antibiotic-resistant bacteria are threatening the arsenal of existing
antibiotics. Not only are antibiotics less likely to be effective today, but their extensive use …

Intravesical bacteriophages for treating urinary tract infections in patients undergoing transurethral resection of the prostate: a randomised, placebo-controlled, double …

L Leitner, A Ujmajuridze, N Chanishvili… - The Lancet Infectious …, 2021 - thelancet.com
Summary Background Urinary tract infections (UTIs) are among the most prevalent microbial
diseases and their financial burden on society is substantial. In the context of increasing …

Bacteriophage therapy: clinical trials and regulatory hurdles

LL Furfaro, MS Payne, BJ Chang - Frontiers in cellular and infection …, 2018 - frontiersin.org
Increasing reports of antimicrobial resistance and limited new antibiotic discoveries and
development have fuelled innovation in other research fields and led to a revitalization of …

Phage cocktail development for bacteriophage therapy: toward improving spectrum of activity breadth and depth

ST Abedon, KM Danis-Wlodarczyk, DJ Wozniak - Pharmaceuticals, 2021 - mdpi.com
Phage therapy is the use of bacterial viruses as antibacterial agents. A primary
consideration for commercial development of phages for phage therapy is the number of …

Fighting pathogenic bacteria on two fronts: phages and antibiotics as combined strategy

TL Tagliaferri, M Jansen, HP Horz - Frontiers in cellular and infection …, 2019 - frontiersin.org
With the emerging threat of infections caused by multidrug resistant bacteria, phages have
been reconsidered as an alternative for treating infections caused by tenacious pathogens …

Unlocking the next generation of phage therapy: the key is in the receptors

FLG Altamirano, JJ Barr - Current Opinion in Biotechnology, 2021 - Elsevier
Highlights•Phages need to attach to a receptor on the bacterial surface to initiate infection.•It
is not common practice to identify these receptors before phage therapy use.•Identifying …

[HTML][HTML] Recent advances in bacteriophage-based therapeutics: Insight into the post-antibiotic era

H Ling, X Lou, Q Luo, Z He, M Sun, J Sun - Acta Pharmaceutica Sinica B, 2022 - Elsevier
Antibiotic resistance is one of the biggest threats to global health, as it can make the
treatment of bacterial infections in humans difficult owing to their high incidence rate …

MRSA compendium of epidemiology, transmission, pathophysiology, treatment, and prevention within one health framework

M Shoaib, AI Aqib, I Muzammil, N Majeed… - Frontiers in …, 2023 - frontiersin.org
Staphylococcus aureus is recognized as commensal as well as opportunistic pathogen of
humans and animals. Methicillin resistant strain of S. aureus (MRSA) has emerged as a …