Standardization of diagnostic criteria for ischemic symptoms due to coronary microvascular
dysfunction (CMD) is needed for further investigation of patients presenting with anginal …

Aims This meta-analysis aims to quantify the association of reduced coronary flow with all-
cause mortality and major adverse cardiovascular events (MACE) across a broad range of …

Importance Coronary artery disease (CAD) and coronary microvascular dysfunction (CMD)
may contribute to the pathophysiologic characteristics of heart failure with preserved ejection …

Ischemic heart disease secondary to coronary vascular dysfunction causes angina and
impairs quality of life and prognosis. About one-half of patients with symptoms and signs of …

Background—Hemodynamically significant coronary artery disease is an important
indication for revascularization. Stress myocardial perfusion imaging is a noninvasive …

In the United States alone, there are currently approximately 14.5 million cancer survivors,
and this number is expected to increase to 20 million by 2020. Cancer therapies can cause …

Background—Discordance between fractional flow reserve (FFR) and coronary flow velocity
reserve (CFVR) may reflect important coronary pathophysiology but usually remains …

The vascular endothelium regulates blood flow in response to physiological needs.
Endothelial dysfunction is closely related to atherosclerosis and its risk factors, and it …

Objectives: This study sought to examine the diagnostic accuracy of the instantaneous wave-
free ratio (iFR) and resting distal coronary artery pressure/aortic pressure (P d/P a) with …

In this review, the authors reflect upon the role of coronary physiology in the modern
management of coronary artery disease. They critically appraise the scientific background of …