Sphingosine-1-phosphate: an enigmatic signalling lipid
S Spiegel, S Milstien - Nature reviews Molecular cell biology, 2003 - nature.com
The evolutionarily conserved actions of the sphingolipid metabolite, sphingosine-1-
phosphate (S1P), in yeast, plants and mammals have shown that it has important functions …
phosphate (S1P), in yeast, plants and mammals have shown that it has important functions …
Sphingosine kinase, sphingosine-1-phosphate, and apoptosis
M Maceyka, SG Payne, S Milstien, S Spiegel - Biochimica et Biophysica …, 2002 - Elsevier
The sphingolipid metabolites ceramide (Cer), sphingosine (Sph), and sphingosine-1-
phosphate (S1P) play an important role in the regulation of cell proliferation, survival, and …
phosphate (S1P) play an important role in the regulation of cell proliferation, survival, and …
SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism
The potent sphingolipid metabolite sphingosine 1-phosphate is produced by
phosphorylation of sphingosine catalyzed by sphingosine kinase (SphK) types 1 and 2. In …
phosphorylation of sphingosine catalyzed by sphingosine kinase (SphK) types 1 and 2. In …
Skeletal muscle triglycerides, diacylglycerols, and ceramides in insulin resistance: another paradox in endurance-trained athletes?
OBJECTIVE Chronic exercise and obesity both increase intramyocellular triglycerides
(IMTGs) despite having opposing effects on insulin sensitivity. We hypothesized that …
(IMTGs) despite having opposing effects on insulin sensitivity. We hypothesized that …
Sphingosine 1-phosphate, a key cell signaling molecule
S Spiegel, S Milstien - Journal of Biological Chemistry, 2002 - ASBMB
The bioactive sphingolipid metabolite sphingosine 1-phosphate (S1P), 1 formed by
phosphorylation of sphingosine catalyzed by sphingosine kinase (Fig. 1), is an important …
phosphorylation of sphingosine catalyzed by sphingosine kinase (Fig. 1), is an important …
[HTML][HTML] Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases
Sphingolipids are ubiquitous components of cell membranes and their metabolites ceramide
(Cer), sphingosine (Sph), and sphingosine-1-phosphate (S1P) have important physiological …
(Cer), sphingosine (Sph), and sphingosine-1-phosphate (S1P) have important physiological …
Autophagosomal membrane serves as platform for intracellular death-inducing signaling complex (iDISC)-mediated caspase-8 activation and apoptosis
Autophagy and apoptosis are two evolutionarily conserved processes that regulate cell fate
in response to cytotoxic stress. However, the functional relationship between these two …
in response to cytotoxic stress. However, the functional relationship between these two …
[HTML][HTML] Lysophospholipid receptors: signalling, pharmacology and regulation by lysophospholipid metabolism
DM Zu Heringdorf, KH Jakobs - Biochimica et Biophysica Acta (BBA) …, 2007 - Elsevier
The lysophospholipids, sphingosine-1-phosphate (S1P), lysophosphatidic acid (LPA),
sphingosylphosphorylcholine (SPC) and lysophosphatidylcholine (LPC), activate diverse …
sphingosylphosphorylcholine (SPC) and lysophosphatidylcholine (LPC), activate diverse …
Sphingosine in apoptosis signaling
O Cuvillier - Biochimica Et Biophysica Acta (BBA)-Molecular and …, 2002 - Elsevier
The sphingolipid metabolites ceramide, sphingosine, and sphingosine 1-phosphate
contribute to controlling cell proliferation and apoptosis. Ceramide and its catabolite …
contribute to controlling cell proliferation and apoptosis. Ceramide and its catabolite …
Sphingosine kinase type 2 is a putative BH3-only protein that induces apoptosis
H Liu, RE Toman, SK Goparaju, M Maceyka… - Journal of Biological …, 2003 - ASBMB
There are two isoforms of sphingosine kinase (SphK) that catalyze the formation of
sphingosine 1-phosphate, a potent sphingolipid mediator. Whereas SphK1 stimulates …
sphingosine 1-phosphate, a potent sphingolipid mediator. Whereas SphK1 stimulates …