The biology of VEGF and its receptors

N Ferrara, HP Gerber, J LeCouter - Nature medicine, 2003 - nature.com
Vascular endothelial growth factor (VEGF) is a key regulator of physiological angiogenesis
during embryogenesis, skeletal growth and reproductive functions. VEGF has also been …

Mechanisms of vessel pruning and regression

C Korn, HG Augustin - Developmental cell, 2015 - cell.com
The field of angiogenesis research has primarily focused on the mechanisms of sprouting
angiogenesis. Yet vascular networks formed by vessel sprouting subsequently undergo …

Vascular endothelial growth factor: basic science and clinical progress

N Ferrara - Endocrine reviews, 2004 - academic.oup.com
Vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen in vitro and
an angiogenic inducer in a variety of in vivo models. Hypoxia has been shown to be a major …

Vascular-specific growth factors and blood vessel formation

GD Yancopoulos, S Davis, NW Gale, JS Rudge… - nature, 2000 - nature.com
A recent explosion in newly discovered vascular growth factors has coincided with
exploitation of powerful new genetic approaches for studying vascular development. An …

VEGF as a key mediator of angiogenesis in cancer

P Carmeliet - Oncology, 2005 - karger.com
Vascular endothelial growth factor (VEGF) is a homodimeric glycoprotein with a molecular
weight of approximately 45 kDa. It is the key mediator of angiogenesis (the formation of new …

Control of vascular morphogenesis and homeostasis through the angiopoietin–Tie system

HG Augustin, G Young Koh, G Thurston… - Nature reviews Molecular …, 2009 - nature.com
Angiogenesis, the growth of blood vessels, is a fundamental biological process that controls
embryonic development and is also involved in numerous life-threatening human diseases …

Role of vascular endothelial growth factor in regulation of physiological angiogenesis

N Ferrara - American Journal of Physiology-Cell …, 2001 - journals.physiology.org
Evidence accumulating over the last decade has established the fundamental role of
vascular endothelial growth factor (VEGF) as a key regulator of normal and abnormal …

Control of hair growth and follicle size by VEGF-mediated angiogenesis

K Yano, LF Brown, M Detmar - The Journal of clinical …, 2001 - Am Soc Clin Investig
The murine hair follicle undergoes pronounced cyclic expansion and regression, leading to
rapidly changing demands for its vascular support. Our study aimed to quantify the cyclic …

The molecular control of corpus luteum formation, function, and regression

C Stocco, C Telleria, G Gibori - Endocrine reviews, 2007 - academic.oup.com
The corpus luteum (CL) is one of the few endocrine glands that forms from the remains of
another organ and whose function and survival are limited in scope and time. The CL is the …

Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by Angiopoietin-1

NW Gale, G Thurston, SF Hackett, R Renard, Q Wang… - Developmental cell, 2002 - cell.com
VEGF and Angiopoietin-1 requisitely collaborate during blood vessel development. While
Angiopoietin-1 obligately activates its Tie2 receptor, Angiopoietin-2 can activate Tie2 on …