Mechanisms of muscle atrophy and hypertrophy: implications in health and disease

R Sartori, V Romanello, M Sandri - Nature communications, 2021 - nature.com
Skeletal muscle is the protein reservoir of our body and an important regulator of glucose
and lipid homeostasis. Consequently, the growth or the loss of muscle mass can influence …

Signaling pathways that control muscle mass

A Vainshtein, M Sandri - International journal of molecular sciences, 2020 - mdpi.com
The loss of skeletal muscle mass under a wide range of acute and chronic maladies is
associated with poor prognosis, reduced quality of life, and increased mortality. Decades of …

Concurrent exercise training: do opposites distract?

VG Coffey, JA Hawley - The Journal of physiology, 2017 - Wiley Online Library
Specificity is a core principle of exercise training to promote the desired adaptations for
maximising athletic performance. The principle of specificity of adaptation is underpinned by …

Molecular mechanisms of skeletal muscle hypertrophy

S Schiaffino, C Reggiani, T Akimoto… - Journal of …, 2021 - journals.sagepub.com
Skeletal muscle hypertrophy can be induced by hormones and growth factors acting directly
as positive regulators of muscle growth or indirectly by neutralizing negative regulators, and …

[HTML][HTML] Mechanisms of adhesion G protein–coupled receptor activation

A Vizurraga, R Adhikari, J Yeung, M Yu… - Journal of Biological …, 2020 - Elsevier
Adhesion G protein–coupled receptors (AGPCRs) are a thirty-three-member subfamily of
Class B GPCRs that control a wide array of physiological processes and are implicated in …

The Role of G Protein–Coupled Receptors and Receptor Kinases in Pancreatic β-Cell Function and Diabetes

MJ Varney, JL Benovic - Pharmacological reviews, 2024 - Elsevier
Abstract Type 2 diabetes (T2D) mellitus has emerged as a major global health concern that
has accelerated in recent years due to poor diet and lifestyle. Afflicted individuals have high …

Meteorin-like facilitates skeletal muscle repair through a Stat3/IGF-1 mechanism

GS Baht, A Bareja, DE Lee, RR Rao, R Huang… - Nature …, 2020 - nature.com
The immune system plays a multifunctional role throughout the regenerative process,
regulating both pro-/anti-inflammatory phases and progenitor cell function. In the present …

Translating the force—mechano-sensing GPCRs

C Wilde, J Mitgau, T Suchý… - American Journal of …, 2022 - journals.physiology.org
Incorporating mechanical cues into cellular responses allows us to experience our direct
environment. Specialized cells can perceive and discriminate between different physical …

The hitchhiker's guide to PGC-1α isoform structure and biological functions

V Martínez-Redondo, AT Pettersson, JL Ruas - Diabetologia, 2015 - Springer
Proteins of the peroxisome proliferator-activated receptor γ (PPARγ) coactivator 1 (PGC-1)
family of transcriptional coactivators coordinate physiological adaptations in many tissues …

Adhesion G protein-coupled receptors: structure, signaling, physiology, and pathophysiology

T Lala, RA Hall - Physiological Reviews, 2022 - journals.physiology.org
Adhesion G protein-coupled receptors: structure, signaling, physiology, and
pathophysiology Page 1 REVIEW ARTICLE ADHESION G PROTEIN-COUPLED …