This study aimed to analyze clinical and regional factors influencing the distribution of
actionable genetic alterations in a large consecutive series of colorectal carcinomas (CRCs) …

The majority of NTRK1, NTRK2, and NTRK3 rearrangements result in increased expression
of the kinase portion of the involved gene due to its fusion to an actively transcribed gene …

The management of lung cancer (LC) requires the analysis of a diverse spectrum of
molecular targets, including kinase activating mutations in EGFR, ERBB2 (HER2), BRAF …

RET-kinase-activating gene rearrangements occur in approximately 1–2% of non-small-cell
lung carcinomas (NSCLCs). Their reliable detection requires next-generation sequencing …

The technique 3'rapid amplification of cDNA ends (3′ RACE) allows for detection of
translocations with unknown gene partners located at the 3′ end of the chimeric transcript …

Introduction Inflammatory myofibroblastic tumours (IMTs), being an exceptionally rare
category of paediatric neoplasms, often contain druggable gene rearrangements involving …

Simple Summary Identifying ALK fusions in advanced non-small-cell lung carcinoma
(aNSCLC) is mandatory for targeted therapy. Current methods use ALK IHC, ALK FISH, or …

The standard for detecting chimeric genes of neurotrophic receptor tyrosine kinases (NTRK)
is next generation sequencing (NGS). However, this analysis is expensive and takes several …

Соматические аберрации в генах тиразиновых ки-наз приводят к стимуляции
сигнальных путей, инициирующих клеточную пролиферацию и ряд других …

Клетки Ca Ski трансдуцировали лентивирусными частицами, кодирующими RT ВИЧ-1
субтипа А под контролем промотора гена фосфоглицераткиназы (PGK). Продукцию RT …