CTCF shapes chromatin structure and gene expression in health and disease
CCCTC‐binding factor (CTCF) is an eleven zinc finger (ZF), multivalent transcriptional
regulator, that recognizes numerous motifs thanks to the deployment of distinct combinations …
regulator, that recognizes numerous motifs thanks to the deployment of distinct combinations …
[HTML][HTML] Beyond genomic weaving: Molecular roles for CTCF outside cohesin loop extrusion
CCCTC-binding factor (CTCF) is a key regulator of 3D genome organization and
transcriptional activity. Beyond its well-characterized role in facilitating cohesin-mediated …
transcriptional activity. Beyond its well-characterized role in facilitating cohesin-mediated …
The SWI/SNF chromatin remodeling complexes BAF and PBAF differentially regulate epigenetic transitions in exhausted CD8+ T cells
CD8+ T cell exhaustion (Tex) limits disease control during chronic viral infections and
cancer. Here, we investigated the epigenetic factors mediating major chromatin-remodeling …
cancer. Here, we investigated the epigenetic factors mediating major chromatin-remodeling …
A cohesin traffic pattern genetically linked to gene regulation
Cohesin-mediated loop extrusion has been shown to be blocked at specific cis-elements,
including CTCF sites, producing patterns of loops and domain boundaries along …
including CTCF sites, producing patterns of loops and domain boundaries along …
BRD9 determines the cell fate of hematopoietic stem cells by regulating chromatin state
M **ao, S Kondo, M Nomura, S Kato… - Nature …, 2023 - nature.com
ATP-dependent chromatin remodeling SWI/SNF complexes exist in three subcomplexes:
canonical BAF (cBAF), polybromo BAF (PBAF), and a newly described non-canonical BAF …
canonical BAF (cBAF), polybromo BAF (PBAF), and a newly described non-canonical BAF …
Loss of PBAF promotes expansion and effector differentiation of CD8+ T cells during chronic viral infection and cancer
During chronic viral infection and cancer, it has been established that a subset of progenitor
CD8+ T cells continuously gives rise to terminally exhausted cells and cytotoxic effector …
CD8+ T cells continuously gives rise to terminally exhausted cells and cytotoxic effector …
[HTML][HTML] Chronic activation of MUC1-C in wound repair promotes progression to cancer stem cells
DW Kufe - Journal of cancer metastasis and treatment, 2022 - ncbi.nlm.nih.gov
Abstract The mucin 1 (MUC1) gene emerged in mammals to afford protection of barrier
epithelial tissues from the external environment. MUC1 encodes a transmembrane C …
epithelial tissues from the external environment. MUC1 encodes a transmembrane C …
Deciphering Molecular Determinants Underlying Penicillium digitatum's Response to Biological and Chemical Antifungal Agents by Tandem Mass Tag (TMT)-Based …
Penicillium digitatum is a widespread pathogen responsible for the postharvest decay of
citrus, one of the most economically important crops worldwide. Currently, chemical …
citrus, one of the most economically important crops worldwide. Currently, chemical …
Role of the cellular factor CTCF in the regulation of bovine leukemia virus latency and three-dimensional chromatin organization
M Bellefroid, A Rodari, M Galais… - Nucleic acids …, 2022 - academic.oup.com
Bovine leukemia virus (BLV)-induced tumoral development is a multifactorial phenomenon
that remains incompletely understood. Here, we highlight the critical role of the cellular …
that remains incompletely understood. Here, we highlight the critical role of the cellular …
At the crossroad of gene regulation and genome organization: Potential roles for ATP-dependent chromatin remodelers in the regulation of CTCF-mediated 3D …
Simple Summary The way DNA is packaged in the nucleus of a cell is important for when
and how genes are expressed. There are many levels of packaging, and new techniques …
and how genes are expressed. There are many levels of packaging, and new techniques …