Epidemiology, pathophysiology and contemporary management of cardiogenic shock–a position statement from the Heart Failure Association of the European Society …

O Chioncel, J Parissis, A Mebazaa… - European journal of …, 2020 - Wiley Online Library
Cardiogenic shock (CS) is a complex multifactorial clinical syndrome with extremely high
mortality, develo** as a continuum, and progressing from the initial insult (underlying …

Microcirculation: physiology, pathophysiology, and clinical application

G Guven, MP Hilty, C Ince - Blood purification, 2020 - karger.com
This paper briefly reviews the physiological components of the microcirculation, focusing on
its function in homeostasis and its central function in the realization of oxygen transport to …

Second consensus on the assessment of sublingual microcirculation in critically ill patients: results from a task force of the European Society of Intensive Care …

C Ince, EC Boerma, M Cecconi, D De Backer… - Intensive care …, 2018 - Springer
Purpose Hand-held vital microscopes (HVMs) were introduced to observe sublingual
microcirculatory alterations at the bedside in different shock states in critically ill patients …

Consensus on circulatory shock and hemodynamic monitoring. Task force of the European Society of Intensive Care Medicine

M Cecconi, D De Backer, M Antonelli, R Beale… - Intensive care …, 2014 - Springer
Objective Circulatory shock is a life-threatening syndrome resulting in multiorgan failure and
a high mortality rate. The aim of this consensus is to provide support to the bedside clinician …

A plea for personalization of the hemodynamic management of septic shock

D De Backer, M Cecconi, MS Chew, L Hajjar, X Monnet… - Critical care, 2022 - Springer
Although guidelines provide excellent expert guidance for managing patients with septic
shock, they leave room for personalization according to patients' condition. Hemodynamic …

Pathophysiology of microcirculatory dysfunction and the pathogenesis of septic shock

D De Backer, D Orbegozo Cortes, K Donadello… - Virulence, 2014 - Taylor & Francis
Multiple experimental and human trials have shown that microcirculatory alterations are
frequent in sepsis. In this review, we discuss the various mechanisms that are potentially …

Direct assessment of microcirculation in shock: a randomized-controlled multicenter study

RR Bruno, J Wollborn, K Fengler, M Flick… - Intensive Care …, 2023 - Springer
Purpose Shock is a life-threatening condition characterized by substantial alterations in the
microcirculation. This study tests the hypothesis that considering sublingual microcirculatory …

Persistent microcirculatory alterations are associated with organ failure and death in patients with septic shock

Y Sakr, MJ Dubois, D De Backer, J Creteur… - Critical care …, 2004 - journals.lww.com
Objective: To characterize the time course of microcirculatory alterations and their relation to
outcome in patients with septic shock. Design: Prospective, observational study. Setting …

How to evaluate the microcirculation: report of a round table conference

D De Backer, S Hollenberg, C Boerma, P Goedhart… - Critical care, 2007 - Springer
Introduction Microvascular alterations may play an important role in the development of
organ failure in critically ill patients and especially in sepsis. Recent advances in technology …

Non-variceal upper gastrointestinal bleeding

A Lanas, JM Dumonceau, RH Hunt… - Nature reviews Disease …, 2018 - nature.com
Non-variceal upper gastrointestinal bleeding (NVUGIB) is bleeding that develops in the
oesophagus, stomach or proximal duodenum. Peptic ulcers, caused by Helicobacter pylori …