Myelin is the protective sheath wrapped around axons, consisting of a phospholipid bilayer
with water between the wraps. The measurement of damage to the myelin sheaths, the …

Neuroinflammation is thought to play a pivotal role in many diseases affecting the brain,
including Alzheimer's disease, multiple sclerosis and stroke. Neuroinflammation is …

At present, spinal cord imaging primarily uses magnetic resonance imaging (MRI) or
computed tomography (CT), but the greater sensitivity of positron emission tomography …

Background Brain PET imaging with different tracers is mainly clinically used in the field of
neurodegenerative diseases and brain tumors. In recent years, the potential usefulness of …

Purpose Upregulation of sphingosine-1-phosphate receptor 1 (S1PR1) expression in
multiple sclerosis (MS) lesions is associated with neuroinflammatory response. This study …

Purpose To evaluate the feasibility and sensitivity of multimodality PET/CT and MRI imaging
for non-invasive characterization of brain microglial/macrophage activation occurring during …

Purpose Neuropathological studies have demonstrated distinct profiles of microglia
activation and myelin injury among different multiple sclerosis (MS) phenotypes and …

Purpose Traumatic spinal cord injury (SCI) is a devastating condition which affects millions
of people worldwide causing major disability and substantial socioeconomic burden. There …

Immune cell–mediated attack on the liver is a defining feature of autoimmune hepatitis and
hepatic allograft rejection. Despite an assortment of diagnostic tools, invasive biopsies …

Purpose Glutamate excitotoxicity contributes to oligodendroglial and axonal damage in
multiple sclerosis pathology. Extracellular glutamate concentration in the brain is controlled …