In the mammalian central nervous system, excitatory glutamatergic synapses harness
neurotransmission that is mediated by ion flow through α-amino-3-hydroxy-5-methyl-4 …

Norepinephrine released by the locus coeruleus modulates cellular processes and synaptic
transmission in the central nervous system through its actions at a number of pre‐and …

The study of synaptic plasticity and specifically LTP and LTD is one of the most active areas
of research in neuroscience. In the last 25 years we have come a long way in our …

The ten-eleven translocation (Tet) family of methylcytosine dioxygenases catalyze oxidation
of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) and promote DNA …

Phosphoinositide 3-kinase (PI3K) signaling contributes to a variety of processes, mediating
many aspects of cellular function, including nutrient uptake, anabolic reactions, cell growth …

Long-term potentiation (LTP) and long-term depression (LTD) comprise the principal cellular
mechanisms that fulfill established criteria for the physiological correlates of learning and …

Synaptic plasticity confers environmental adaptability through modification of the
connectivity between neurons and neuronal circuits. This is achieved through changes to …

The ability to rapidly adapt to novel situations is essential for survival, and this flexibility is
impaired in many neuropsychiatric disorders. Thus, understanding whether and how novelty …

Tau is required for the induction of long-term depression (LTD) of synaptic transmission in
the hippocampus. Here we probe the role of tau in LTD, finding that an AMPA receptor …

Protein SUMOylation is a critically important posttranslational protein modification that
participates in nearly all aspects of cellular physiology. In the nearly 20 years since its …