Histone modifications are key epigenetic regulators that control chromatin structure and
gene transcription, thereby impacting on various important cellular phenotypes. Over the …

Reducing body weight to improve metabolic health and related comorbidities is a primary
goal in treating obesity,. However, maintaining weight loss is a considerable challenge …

Liver fibrosis is a strong predictor of long-term mortality in individuals with metabolic-
associated fatty liver disease; yet, the mechanisms underlying the progression from the …

Insulin resistance (IR) is largely recognized as a unifying feature that underlies metabolic
dysfunction. Both lifestyle and genetic factors contribute to IR. Work from recent years has …

Abstract C57BL/6J-related mouse strains are widely used animal models for diet-induced
obesity (DIO). Multiple vendors breed C57BL/6J-related substrains which may introduce …

The glucocorticoid receptor (GR) is a potent metabolic regulator and a major drug target.
While GR is known to play integral roles in circadian biology, its rhythmic genomic actions …

Thyroid hormone (TH) and TH receptors (TRs) α and β act by binding to TH response
elements (TREs) in regulatory regions of target genes. This nuclear signaling is established …

Insulin resistance results from an intricate interaction between genetic make-up and
environment, and thus may be orchestrated by epigenetic mechanisms like DNA …

Metabolic adaptation to nutritional state requires alterations in gene expression in key
tissues. Here, we investigated chromatin interaction dynamics, as well as alterations in cis …