Summary The sphingosine 1-phosphate (S1P) signalling pathways have important and
diverse functions. S1P receptors (S1PRs) have been proposed as a therapeutic target for …

Introduction Multiple sclerosis (MS) is an immune-mediated disorder of the CNS manifested
by recurrent attacks of neurological symptoms (related to focal inflammation) and gradual …

After experiencing the COVID-19 pandemic, it is widely acknowledged that a rapid drug
repurposing method is highly needed. A series of useful drug repurposing tools have been …

As viruses are obligatory intracellular parasites, any step during their life cycle strictly
depends on successful interaction with their particular host cells. In particular, their …

Antiretroviral therapy (ART) is not curative due to the persistence of a reservoir of HIV-
infected cells, particularly in tissues such as lymph nodes, with the potential to cause viral …

With the aging of the global population, older people living with HIV (OPLWH) have
emerged as a focal point in HIV/AIDS research. Although antiretroviral therapy has …

CCR5 is the main HIV co-receptor. We aimed to (1) compare CCR5 expression on immune
cells between people living with HIV (PLHIV) using combination antiretroviral therapy …

The establishment of HIV-1 latency has hindered an HIV-1 cure.“Shock and kill” strategies to
target this reservoir aim to induce the latent provirus with latency-reversing agents (LRAs) …

ABSTRACT Sphingosine-1-phosphate (S1P) is a sphingolipid modulator of a myriad of
cellular processes, and therapeutic targeting of S1P signaling is utilized clinically to treat …

Lysophospholipids are a class of simple phospholipids that shows their biological effects
through various G protein-coupled receptors (GPCRs). Sphingosine 1-phosphate (S1P) is …