Bone remodeling is tightly controlled by osteoclast-mediated bone resorption and osteoblast-
mediated bone formation. Fine tuning of the osteoclast–osteoblast balance results in strict …

Bone metabolism is a lifelong process that includes bone formation and resorption.
Osteoblasts and osteoclasts are the predominant cell types associated with bone …

Background Chronic nonbacterial osteomyelitis (CNO) is a rare, and impactful auto-
inflammatory bone disease occurring in children and adults. Clinical care for CNO is …

Objectives Chronic nonbacterial osteomyelitis (CNO) is a rare inflammatory bone disease.
The distinct CNO subtype that affects the anterior chest wall is descriptively named …

Chronic nonbacterial osteomyelitis (CNO) is an auto-inflammatory bone disorder with a wide
spectrum of clinical manifestations, from unifocal to multifocal lesions. When it manifests with …

Chronic nonbacterial osteitis (CNO) is a rare musculoskeletal disease causing chronic bone
pain. It is known that chronic musculoskeletal pain may involve other mechanisms than …

Autoinflammatory diseases are disorders of the innate immune system, which can be either
monogenic due to a specific genetic mutation or complex multigenic due to the involvement …

Background There is considerable practice variation in labelling, diagnosis and treatment of
adults with sterile bone inflammation. We developed a expert consensus recommendations …

Chronic nonbacterial osteitis (CNO) is a rare auto-inflammatory bone disease affecting
children and adults. Adult CNO is characterized by painful bone lesions, primarily of the …

Chronic nonbacterial osteomyelitis (CNO), an autoinflammatory bone disease primarily
affecting children, can cause pain, hyperostosis and fractures, affecting quality-of-life and …