Seizures in patients presenting with mesial temporal lobe epilepsy result from the interaction
among neuronal networks in limbic structures such as the hippocampus, amygdala and …

Epileptic seizures occur as a result of episodic abnormal synchronous discharges in
cerebral neuronal networks. Although a variety of non‐conventional mechanisms may play a …

Despite neuropathological and electrophysiological evidence for the involvement of
parahippocampal structures in temporal lobe epilepsy (TLE), little attention has been paid to …

GABA is the main inhibitory neurotransmitter in the adult forebrain, where it activates
ionotropic type A and metabotropic type B receptors. Early studies have shown that GABAA …

Continuous application of 4-aminopyridine (4-AP, 50 μm) to combined slices of
hippocampus–entorhinal cortex obtained from adult mice induces (1) interictal discharges …

Understanding neural network behavior is essential to shed light on epileptogenesis and
seizure propagation. The interconnectivity and plasticity of mammalian limbic and …

Application of 4-aminopyridine (4AP, 50 μm) to combined slices of adult rat hippocampus–
entorhinal cortex-induced ictal and interictal epileptiform discharges, as well as slow field …

Key points In focal epilepsy the propagation of seizure discharges arising at restricted brain
sites is opposed by feedforward inhibition. Failure of this inhibition marks focal seizure …

In vitro expanded neural stem/progenitor cells can undergo region-specific differentiation
after transplantation to the develo** or adult brain, and display morphologies and markers …

On the basis of neuroanatomical studies, the entorhmal cortex (EC) has long been regarded
as a relay station that provides the major source of afferent input to the hippocampus. The …