Phagocytosis of necrotic debris at sites of injury and inflammation

J Westman, S Grinstein, PE Marques - Frontiers in immunology, 2020 - frontiersin.org
Clearance of cellular debris is required to maintain the homeostasis of multicellular
organisms. It is intrinsic to processes such as tissue growth and remodeling, regeneration …

Eicosanoids and other oxylipins in liver injury, inflammation and liver cancer development

MM Alba, B Ebright, B Hua, I Slarve, Y Zhou… - Frontiers in …, 2023 - frontiersin.org
Liver cancer is a malignancy developed from underlying liver disease that encompasses
liver injury and metabolic disorders. The progression from these underlying liver disease to …

Vanillic acid inhibits inflammatory pain by inhibiting neutrophil recruitment, oxidative stress, cytokine production, and NFκB activation in mice

C Calixto-Campos, TT Carvalho… - Journal of natural …, 2015 - ACS Publications
Vanillic acid (1) is a flavoring agent found in edible plants and fruits. It is an oxidized form of
vanillin. Phenolic compounds form a substantial part of plant foods used as antioxidants with …

[HTML][HTML] Protective effects of the flavonoid hesperidin methyl chalcone in inflammation and pain in mice: role of TRPV1, oxidative stress, cytokines and NF-κB

FA Pinho-Ribeiro, MSN Hohmann, SM Borghi… - Chemico-biological …, 2015 - Elsevier
Cytokines and reactive oxygen species are inflammatory mediators that lead to increased
sensitivity to painful stimuli, and their inhibition represents a therapeutic approach in …

Naringenin Inhibits Superoxide Anion-Induced Inflammatory Pain: Role of Oxidative Stress, Cytokines, Nrf-2 and the NO−cGMP−PKG−KATPChannel Signaling …

MF Manchope, C Calixto-Campos, L Coelho-Silva… - PloS one, 2016 - journals.plos.org
In the present study, the effect and mechanism of action of the flavonoid naringenin were
evaluated in superoxide anion donor (KO2)-induced inflammatory pain in mice. Naringenin …

The citrus flavonone naringenin reduces lipopolysaccharide-induced inflammatory pain and leukocyte recruitment by inhibiting NF-κB activation

FA Pinho-Ribeiro, AC Zarpelon, SS Mizokami… - The Journal of nutritional …, 2016 - Elsevier
Lipopolysaccharide (LPS) is the major structural component of Gram-negative bacteria cell
wall and a highly pro-inflammatory toxin. Naringenin is found in Citrus fruits and exhibits …

Anti-inflammatory activity of betalain-rich dye of Beta vulgaris: effect on edema, leukocyte recruitment, superoxide anion and cytokine production

RM Martinez, DT Longhi-Balbinot, AC Zarpelon… - Archives of Pharmacal …, 2015 - Springer
We have recently developed betalain-rich beetroot (Beta vulgaris) dye (betalain) to be used
in food products. Betalain (30–300 mg/kg) intraperitoneal (ip) treatment diminished …

The flavonoid quercetin inhibits titanium dioxide (TiO2)-induced chronic arthritis in mice

SM Borghi, SS Mizokami, FA Pinho-Ribeiro… - The Journal of …, 2018 - Elsevier
Titanium dioxide (TiO 2) is a common component of orthopedic prosthesis. However,
prosthesis wear releases TiO 2, which induces inflammation and osteolysis in peri-prosthetic …

Ameliorative effect of montelukast against carbon tetrachloride-induced hepatotoxicity: Targeting NLRP3 inflammasome pathway

DH El-Kashef, RA Zaghloul - Life Sciences, 2022 - Elsevier
Aims Montelukast, a selective antagonist of type 1 cysteinyl-leukotriene receptors, has
antioxidant and anti-inflammatory abilities. This study aimed to explore its hepatoprotective …

[HTML][HTML] Vinpocetine reduces lipopolysaccharide-induced inflammatory pain and neutrophil recruitment in mice by targeting oxidative stress, cytokines and NF-κB

KW Ruiz-Miyazawa, FA Pinho-Ribeiro… - Chemico-biological …, 2015 - Elsevier
In response to lipopolysaccharide (LPS), tissue resident macrophages and recruited
neutrophils produce inflammatory mediators through activation of Toll-like receptor 4 …