Vitamin E therapy beyond cancer: Tocopherol versus tocotrienol

HY Peh, WSD Tan, W Liao, WSF Wong - Pharmacology & therapeutics, 2016 - Elsevier
The discovery of vitamin E (α-tocopherol) began in 1922 as a vital component required in
reproduction. Today, there are eight naturally occurring vitamin E isoforms, namely α-, β-, γ …

Therapeutic potential of palm oil vitamin E-derived tocotrienols in inflammation and chronic diseases: Evidence from preclinical and clinical studies

Z Zainal, H Khaza'ai, AK Radhakrishnan… - Food Research …, 2022 - Elsevier
Palm oil is rich in tocotrienols (T3s), a type of vitamin E that has garnered considerable
research interest as it exhibits anti-inflammatory as well as antioxidant characteristics that …

Vitamin E as a potential interventional treatment for metabolic syndrome: evidence from animal and human studies

SK Wong, KY Chin, FH Suhaimi, F Ahmad… - Frontiers in …, 2017 - frontiersin.org
A constellation of medical conditions inclusive of central obesity, hyperglycemia,
hypertension, and dyslipidemia is known as metabolic syndrome (MetS). The safest option …

[HTML][HTML] Potential role of tocotrienols on non-communicable diseases: a review of current evidence

SK Wong, Y Kamisah, N Mohamed, N Muhammad… - Nutrients, 2020 - mdpi.com
Tocotrienol (T3) is a subfamily of vitamin E known for its wide array of medicinal properties.
This review aimed to summarize the health benefits of T3, particularly in prevention or …

The role of tocotrienol in protecting against metabolic diseases

KL Pang, KY Chin - Molecules, 2019 - mdpi.com
Obesity is a major risk factor for diabetes, and these two metabolic conditions cause
significant healthcare burden worldwide. Chronic inflammation and increased oxidative …

Gamma-tocotrienol attenuates high-fat diet-induced obesity and insulin resistance by inhibiting adipose inflammation and M1 macrophage recruitment

L Zhao, I Kang, X Fang, W Wang, MA Lee… - International Journal of …, 2015 - nature.com
Methods: Young C57BL/6J mice were fed a high-fat (HF) diet supplemented with 0.05% γT3
for 4 weeks. The concentrations of γT3 in plasma and adipose tissue were measured using …

[HTML][HTML] Antioxidant and anti-apoptotic effects of tocotrienol-rich fraction against streptozotocin-induced diabetic retinopathy in rats

MZ Sadikan, NAA Nasir, I Iezhitsa, R Agarwal - Biomedicine & …, 2022 - Elsevier
Oxidative stress, a key player in diabetic retinopathy (DR), is associated with retinal cell
apoptosis. This study investigated the effect of tocotrienol-rich fraction (TRF), a potent …

The effects of palm tocotrienol on metabolic syndrome and bone loss in male rats induced by high-carbohydrate high-fat diet

SK Wong, KY Chin, FH Suhaimi, F Ahmad… - Journal of Functional …, 2018 - Elsevier
Inflammation is a possible mediator of the relationship between metabolic syndrome (MetS)
and osteoporosis. Palm tocotrienol, an anti-inflammatory agent, has been reported to exert …

Tocotrienol and its role in chronic diseases

KY Chin, KL Pang, IN Soelaiman - Anti-inflammatory nutraceuticals and …, 2016 - Springer
Tocotrienol is a member of vitamin E family and is well-known for its antioxidant and anti-
inflammatory properties. It is also a suppressor of mevalonate pathway responsible for …

[HTML][HTML] The ameliorative effects of a tocotrienol-rich fraction on the AGE-RAGE axis and hypertension in high-fat-diet-fed rats with metabolic syndrome

HS Cheng, SH Ton, JBL Tan, K Abdul Kadir - Nutrients, 2017 - mdpi.com
The clinical value of tocotrienols is increasingly appreciated because of the unique
therapeutic effects that are not shared by tocopherols. However, their effect on metabolic …