Unravelling the mechanisms of durable control of HIV-1
Untreated HIV-1 infection typically progresses to AIDS within 10 years, but less than 1% of
infected individuals remain healthy and have normal CD4+ T cell counts and undetectable …
infected individuals remain healthy and have normal CD4+ T cell counts and undetectable …
The split personality of regulatory T cells in HIV infection
MF Chevalier, L Weiss - Blood, The Journal of the American …, 2013 - ashpublications.org
Natural regulatory T cells (Tregs) participate in responses to various chronic infections
including HIV. HIV infection is associated with a progressive CD4 lymphopenia and …
including HIV. HIV infection is associated with a progressive CD4 lymphopenia and …
Comprehensive Analysis of Frequency and Phenotype of T Regulatory Cells in HIV Infection: CD39 Expression of FoxP3+ T Regulatory Cells Correlates with …
J Schulze zur Wiesch, A Thomssen, P Hartjen… - Journal of …, 2011 - Am Soc Microbiol
There are conflicting data about the frequency and role of regulatory T cells (Tregs) during
the course of HIV infection. Peripheral blood of a large cohort of HIV-infected patients (n …
the course of HIV infection. Peripheral blood of a large cohort of HIV-infected patients (n …
Human T cells express CD25 and Foxp3 upon activation and exhibit effector/memory phenotypes without any regulatory/suppressor function
M Kmieciak, M Gowda, L Graham, K Godder… - Journal of translational …, 2009 - Springer
Background Foxp3 has been suggested to be a standard marker for murine Tregs whereas
its role as marker for human Tregs is controversial. While some reports have shown that …
its role as marker for human Tregs is controversial. While some reports have shown that …
Exploiting mucosal immunity for antiviral vaccines
A Iwasaki - Annual review of immunology, 2016 - annualreviews.org
Mucosal surfaces provide a remarkably effective barrier against potentially dangerous
pathogens. Therefore, enhancing mucosal immunity through vaccines—strengthening that …
pathogens. Therefore, enhancing mucosal immunity through vaccines—strengthening that …
A low T regulatory cell response may contribute to both viral control and generalized immune activation in HIV controllers
HIV-infected individuals maintaining undetectable viremia in the absence of therapy (HIV
controllers) often maintain high HIV-specific T cell responses, which has spurred the …
controllers) often maintain high HIV-specific T cell responses, which has spurred the …
Immune activation, apoptosis, and Treg activity are associated with persistently reduced CD4+ T-cell counts during antiretroviral therapy
Background: Persistently reduced CD4+ T-lymphocyte counts in the face of undetectable
HIV viremia are seen in a sizable percentage of HIV-infected patients undergoing …
HIV viremia are seen in a sizable percentage of HIV-infected patients undergoing …
Follicular regulatory T cells impair follicular T helper cells in HIV and SIV infection
Human and simian immunodeficiency viruses (HIV and SIV) exploit follicular lymphoid
regions by establishing high levels of viral replication and dysregulating humoral immunity …
regions by establishing high levels of viral replication and dysregulating humoral immunity …
Impact of estrogen and progesterone on immune cells and host–pathogen interactions in the lower female reproductive tract
MK Collins, CR McCutcheon… - The Journal of …, 2022 - journals.aai.org
Microbial infections are a threat to women's reproductive health. Although reproductive
cycles and pregnancy are controlled by sex hormones, the impact of hormones on host …
cycles and pregnancy are controlled by sex hormones, the impact of hormones on host …
HIV-Exposed Seronegative Commercial Sex Workers Show a Quiescent Phenotype in the CD4+ T Cell Compartment and Reduced Expression of HIV-Dependent …
Studies of human immunodeficiency virus (HIV)-exposed seronegative individuals are
crucial to inform vaccine design. In the present study we demonstrated that HIV-exposed …
crucial to inform vaccine design. In the present study we demonstrated that HIV-exposed …