The nuclear lamina in health and disease
The nuclear lamina (NL) is a structural component of the nuclear envelope and makes
extensive contacts with integral nuclear membrane proteins and chromatin. These …
extensive contacts with integral nuclear membrane proteins and chromatin. These …
The multifaceted roles of RCC1 in tumorigenesis
X Ren, K Jiang, F Zhang - Frontiers in Molecular Biosciences, 2020 - frontiersin.org
RCC1 (regulator of chromosome condensation 1) is the only known guanine nucleotide
exchange factor of Ran, a nuclear Ras-like G protein. RCC1 combines with chromatin and …
exchange factor of Ran, a nuclear Ras-like G protein. RCC1 combines with chromatin and …
AKTs do not translocate to the nucleus upon stimulation but AKT3 can constitutively signal from the nuclear envelope
AKT is a central signaling protein kinase that plays a role in the regulation of cellular survival
metabolism and cell growth, as well as in pathologies such as diabetes and cancer. Human …
metabolism and cell growth, as well as in pathologies such as diabetes and cancer. Human …
PI3Kβ—A Versatile Transducer for GPCR, RTK, and Small GTPase Signaling
AR Bresnick, JM Backer - Endocrinology, 2019 - academic.oup.com
Abstract The phosphoinositide 3-kinase (PI3K) family includes eight distinct catalytic
subunits and seven regulatory subunits. Only two PI3Ks are directly regulated downstream …
subunits and seven regulatory subunits. Only two PI3Ks are directly regulated downstream …
p110α and p110β isoforms of PI 3K signaling: are they two sides of the same coin?
Class‐1 phosphatidylinositol‐3‐kinases (PI 3Ks) are activated by a variety of extracellular
stimuli and have been implicated in a wide range of cellular processes. p110α and p110β …
stimuli and have been implicated in a wide range of cellular processes. p110α and p110β …
Epstein–Barr virus nuclear antigen 1 interacts with regulator of chromosome condensation 1 dynamically throughout the cell cycle
The Epstein–Barr virus (EBV) nuclear antigen 1 (EBNA1) is a sequence-specific DNA-
binding protein that plays an essential role in viral episome replication and segregation, by …
binding protein that plays an essential role in viral episome replication and segregation, by …
Structural insights into the origin of phosphoinositide 3-kinase inhibition
Class I phosphoinositide 3-kinases (PI3Ks) are currently considered as significant targets for
the development of novel pharmaceuticals to treat cancers and inflammatory diseases …
the development of novel pharmaceuticals to treat cancers and inflammatory diseases …
The intricate roles of RCC1 in normal cells and cancer cells
L **g, HF Kwok - Biochemical Society Transactions, 2022 - portlandpress.com
RCC1 (regulator of chromosome condensation 1) is a highly conserved chromatin-binding
protein and the only known guanine-nucleotide exchange factor of Ran (a nuclear Ras …
protein and the only known guanine-nucleotide exchange factor of Ran (a nuclear Ras …
[HTML][HTML] The natural adaptive evolution of cancer: The metastatic ability of cancer cells
The ability of cancer to adapt renders it one of the most challenging pathologies of all time. It
is the most dreaded pathological entity because of its capacity to metastasize to distant sites …
is the most dreaded pathological entity because of its capacity to metastasize to distant sites …
Upregulation of nicotinic acetylcholine receptor alph4+ beta2 through a ligand-independent PI3Kbeta mechanism that is enhanced by TNFalpha and the Jak2 …
SW Rogers, LC Gahring - Plos one, 2015 - journals.plos.org
High affinity nicotine-binding sites in the mammalian brain are neuronal nicotinic
acetylcholine receptors (nAChR) assembled from at least alpha4 and beta2 subunits into …
acetylcholine receptors (nAChR) assembled from at least alpha4 and beta2 subunits into …