U-shaped association of uric acid to overall-cause mortality and its impact on clinical management of hyperuricemia
WT Crawley, CG Jungels, KR Stenmark, MA Fini - Redox Biology, 2022 - Elsevier
Serum uric acid (SUA) is significantly elevated in obesity, gout, type 2 diabetes mellitus, and
the metabolic syndrome and appears to contribute to the renal, cardiovascular and …
the metabolic syndrome and appears to contribute to the renal, cardiovascular and …
[HTML][HTML] The role of xanthine oxidoreductase and uric acid in metabolic syndrome
Xanthine oxidoreductase (XOR) could contribute to the pathogenesis of metabolic syndrome
through the oxidative stress and the inflammatory response induced by XOR-derived …
through the oxidative stress and the inflammatory response induced by XOR-derived …
The role of uric acid as an endogenous danger signal in immunity and inflammation
Gout is an ancient disease that still plagues us. Its pathogenic culprit, uric acid crystal
deposition in tissues, is a strong inflammatory stimulant. In recent years, the mechanisms …
deposition in tissues, is a strong inflammatory stimulant. In recent years, the mechanisms …
Significance of serum uric acid levels on the risk of all-cause and cardiovascular mortality
Objective. To assess the associations between serum uric acid (SUA) level and mortality.
Methods. The study included 354 110 subjects without a history of gout and whose SUA …
Methods. The study included 354 110 subjects without a history of gout and whose SUA …
Oxidative damage in Parkinson disease: Measurement using accurate biomarkers
Oxidative damage has been implicated in the pathogenesis of Parkinson disease (PD) but
the literature data are confusing. Using products of lipid and DNA oxidation measured by …
the literature data are confusing. Using products of lipid and DNA oxidation measured by …
[HTML][HTML] The clinical value of serum xanthine oxidase levels in patients with acute ischemic stroke
H Yu, X Chen, X Guo, D Chen, L Jiang, Y Qi, J Shao… - Redox Biology, 2023 - Elsevier
Xanthine oxidase (XO), a form of xanthine oxidoreductase, is widely distributed in various
human tissues. As a major source for the generation of superoxide radicals, XO is involved …
human tissues. As a major source for the generation of superoxide radicals, XO is involved …
Why does hyperuricemia not necessarily induce gout?
WZ Zhang - Biomolecules, 2021 - mdpi.com
Hyperuricemia is a risk factor for gout. It has been well observed that a large proportion of
individuals with hyperuricemia have never had a gout flare (s), while some patients with gout …
individuals with hyperuricemia have never had a gout flare (s), while some patients with gout …
Serum uric acid levels and outcomes after acute ischemic stroke
Z Wang, Y Lin, Y Liu, Y Chen, B Wang, C Li, S Yan… - Molecular …, 2016 - Springer
Previous studies assessing the association between serum uric acid levels and neurological
outcome after acute ischemic stroke reported conflicting results. A systematic review and …
outcome after acute ischemic stroke reported conflicting results. A systematic review and …
Uric acid levels are relevant in patients with stroke treated with thrombolysis
Background and Purpose—Uric acid (UA) is a neuroprotective antioxidant that improves the
benefits of alteplase in experimental ischemia. However, it is unknown whether endogenous …
benefits of alteplase in experimental ischemia. However, it is unknown whether endogenous …
[HTML][HTML] Linking uric acid metabolism to diabetic complications
A Kushiyama, K Tanaka, S Hara… - World journal of …, 2014 - ncbi.nlm.nih.gov
Hyperuricemia have been thought to be caused by the ingestion of large amounts of
purines, and prevention or treatment of hyperuricemia has intended to prevent gout …
purines, and prevention or treatment of hyperuricemia has intended to prevent gout …