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Sex differences in biological aging with a focus on human studies
Aging is a complex biological process characterized by hallmark features accumulating over
the life course, sha** the individual's aging trajectory and subsequent disease risks. There …
the life course, sha** the individual's aging trajectory and subsequent disease risks. There …
Programmed cell death in aging
Programmed cell death (PCD) pathways, including apoptosis and regulated necrosis, are
required for normal cell turnover and tissue homeostasis. Mis-regulation of PCD is …
required for normal cell turnover and tissue homeostasis. Mis-regulation of PCD is …
Sex differences in adult lifespan and aging rates of mortality across wild mammals
In human populations, women consistently outlive men, which suggests profound biological
foundations for sex differences in survival. Quantifying whether such sex differences are also …
foundations for sex differences in survival. Quantifying whether such sex differences are also …
Early-late life trade-offs and the evolution of ageing in the wild
Empirical evidence for declines in fitness components (survival and reproductive
performance) with age has recently accumulated in wild populations, highlighting that the …
performance) with age has recently accumulated in wild populations, highlighting that the …
Urgent needs of caregiving in ageing populations with Alzheimer's disease and other chronic conditions: support our loved ones
The ageing process begins at birth. It is a life-long process, and its exact origins are still
unknown. Several hypotheses attempt to describe the normal ageing process, including …
unknown. Several hypotheses attempt to describe the normal ageing process, including …
Sex differences in the gut microbiome–brain axis across the lifespan
In recent years, the bidirectional communication between the gut microbiome and the brain
has emerged as a factor that influences immunity, metabolism, neurodevelopment and …
has emerged as a factor that influences immunity, metabolism, neurodevelopment and …
Oxidative stress and hormesis in evolutionary ecology and physiology
Research programmes on oxidative stress and hormesis are wide ranging. Biomedical and
toxicological sciences have traditionally centralised such research, but in the last years we …
toxicological sciences have traditionally centralised such research, but in the last years we …
The sex with the reduced sex chromosome dies earlier: a comparison across the tree of life
Many taxa show substantial differences in lifespan between the sexes. However, these
differences are not always in the same direction. In mammals, females tend to live longer …
differences are not always in the same direction. In mammals, females tend to live longer …
Sex‐specific aging in animals: perspective and future directions
Sex differences in aging occur in many animal species, and they include sex differences in
lifespan, in the onset and progression of age‐associated decline, and in physiological and …
lifespan, in the onset and progression of age‐associated decline, and in physiological and …
Sex gap in aging and longevity: can sex chromosomes play a role?
It is well known that women live longer than men. This gap is observed in most human
populations and can even reach 10–15 years. In addition, most of the known super …
populations and can even reach 10–15 years. In addition, most of the known super …