Epithelial–mesenchymal plasticity (EMP) enables cells to interconvert between several
states across the epithelial–mesenchymal landscape, thereby acquiring hybrid epithelial …

Breast cancer is one of the most common malignancy among women worldwide. Metastasis
is mainly responsible for treatment failure and is the cause of most breast cancer deaths …

The epithelial to mesenchymal transition (EMT) is a key cellular process underlying cancer
progression, with multiple intermediate states whose molecular hallmarks remain poorly …

The plasticity of cancer cells underlies their capacity to adapt to the selective pressures they
encounter during tumour development. Aberrant reactivation of epithelial–mesenchymal …

Epithelial-mesenchymal transition (EMT) of adherent epithelial cells to a migratory
mesenchymal state has been implicated in tumor metastasis in preclinical models. To …

The EGFR/PI3K/PTEN/Akt/mTORC1/GSK-3 pathway plays prominent roles in malignant
transformation, prevention of apoptosis, drug resistance and metastasis. The expression of …

The Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades are often activated by genetic
alterations in upstream signaling molecules such as receptor tyrosine kinases (RTK) …

Achieving precise cancer theranostics necessitates the rational design of smart
nanosystems that ensure high biological safety and minimize non-specific interactions with …

Background microRNAs have been established as powerful regulators of gene expression
in normal physiological as well as in pathological conditions, including cancer progression …

A switch from catabolic to anabolic metabolism, a major hallmark of cancer, enables rapid
cell duplication, and is driven by multiple oncogenic alterations, including PIK3CA mutation …