[HTML][HTML] Diabetes mellitus: Classification, mediators, and complications; A gate to identify potential targets for the development of new effective treatments

SA Antar, NA Ashour, M Sharaky, M Khattab… - Biomedicine & …, 2023 - Elsevier
Nowadays, diabetes mellitus has emerged as a significant global public health concern with
a remarkable increase in its prevalence. This review article focuses on the definition of …

Emerging targets in type 2 diabetes and diabetic complications

S Demir, PP Nawroth, S Herzig… - Advanced …, 2021 - Wiley Online Library
Type 2 diabetes is a metabolic, chronic disorder characterized by insulin resistance and
elevated blood glucose levels. Although a large drug portfolio exists to keep the blood …

Genetics of diabetes mellitus and diabetes complications

JB Cole, JC Florez - Nature reviews nephrology, 2020 - nature.com
Diabetes is one of the fastest growing diseases worldwide, projected to affect 693 million
adults by 2045. Devastating macrovascular complications (cardiovascular disease) and …

New horizons in diabetic neuropathy: mechanisms, bioenergetics, and pain

EL Feldman, KA Nave, TS Jensen, DLH Bennett - Neuron, 2017 - cell.com
Pre-diabetes and diabetes are a global epidemic, and the associated neuropathic
complications create a substantial burden on both the afflicted patients and society as a …

A new look at painful diabetic neuropathy

G Sloan, P Shillo, D Selvarajah, J Wu… - Diabetes research and …, 2018 - Elsevier
The prevalence of diabetes mellitus and its chronic complications continue to increase
alarmingly. Consequently, the massive expenditure on diabetic distal symmetrical …

Cardiovascular autonomic neuropathy in diabetes: Pathophysiology, clinical assessment and implications

A Duque, MFF Mediano, A De Lorenzo… - World journal of …, 2021 - pmc.ncbi.nlm.nih.gov
Cardiovascular autonomic neuropathy (CAN) is a debilitating condition that mainly occurs in
long-standing type 2 diabetes patients but can manifest earlier, even before diabetes is …

Understanding the role of hyperglycemia and the molecular mechanism associated with diabetic neuropathy and possible therapeutic strategies

M Kaur, S Misra, P Swarnkar, P Patel, BD Kurmi… - Biochemical …, 2023 - Elsevier
Diabetic neuropathy is a neuro-degenerative disorder that encompasses numerous factors
that impact peripheral nerves in the context of diabetes mellitus (DM). Diabetic peripheral …

Transcriptomic analysis of human sensory neurons in painful diabetic neuropathy reveals inflammation and neuronal loss

BE Hall, E Macdonald, M Cassidy, S Yun, MR Sapio… - Scientific reports, 2022 - nature.com
Pathological sensations caused by peripheral painful neuropathy occurring in Type 2
diabetes mellitus (T2DM) are often described as 'sharp'and 'burning'and are commonly …

Mangiferin Alleviates Renal Interstitial Fibrosis in Streptozotocin‐Induced Diabetic Mice through Regulating the PTEN/PI3K/Akt Signaling Pathway

Y Song, W Liu, K Tang, J Zang, D Li… - Journal of Diabetes …, 2020 - Wiley Online Library
Renal interstitial fibrosis is considered to be the typical manifestation of diabetic
nephropathy (DN). Mangiferin has shown positive effect on the prevention or treatment of …

Diabetes and the risk of sudden cardiac death

J Svane, U Pedersen-Bjergaard… - Current cardiology …, 2020 - Springer
Abstract Purpose of Review Persons with diabetes mellitus (DM) have increased morbidity
and mortality rates compared with persons without DM. Sudden cardiac death (SCD) is a …