Osteoarthritis associated with estrogen deficiency
JA Roman-Blas, S Castañeda, R Largo… - Arthritis research & …, 2009 - Springer
Osteoarthritis (OA) affects all articular tissues and finally leads to joint failure. Although
articular tissues have long been considered unresponsive to estrogens or their deficiency …
articular tissues have long been considered unresponsive to estrogens or their deficiency …
Subchondral bone as a key target for osteoarthritis treatment
S Castañeda, JA Roman-Blas, R Largo… - Biochemical …, 2012 - Elsevier
Osteoarthritis (OA), the most common form of arthritis, is a debilitating and progressive
disease that has become a major cause of disability and impaired quality of life in the …
disease that has become a major cause of disability and impaired quality of life in the …
The coupling of bone and cartilage turnover in osteoarthritis: opportunities for bone antiresorptives and anabolics as potential treatments?
Osteoarthritis (OA) is the most common form of arthritic disease, and a major cause of
disability and impaired quality of life in the elderly. OA is a complex disease of the entire …
disability and impaired quality of life in the elderly. OA is a complex disease of the entire …
Beyond cartilage repair: the role of the osteochondral unit in joint health and disease
Once believed to be limited to articular cartilage, osteoarthritis is now considered to be an
organ disease of the “whole joint.” Damage to the articular surface can lead to, be caused …
organ disease of the “whole joint.” Damage to the articular surface can lead to, be caused …
Subchondral bone microstructural damage by increased remodelling aggravates experimental osteoarthritis preceded by osteoporosis
M Bellido, L Lugo, JA Roman-Blas, S Castañeda… - Arthritis research & …, 2010 - Springer
Introduction Osteoporosis (OP) increases cartilage damage in a combined rabbit model of
OP and osteoarthritis (OA). Accordingly, we assessed whether microstructure impairment at …
OP and osteoarthritis (OA). Accordingly, we assessed whether microstructure impairment at …
[HTML][HTML] Should subchondral bone turnover be targeted when treating osteoarthritis?
OBJECTIVE: Osteoarthritis (OA) is the most common form of arthritic disease, and it is a
major cause of disability and impaired quality of life in the elderly. OA is a complex disease …
major cause of disability and impaired quality of life in the elderly. OA is a complex disease …
[HTML][HTML] Animal models for osteoarthritis: the effect of ovariectomy and estrogen treatment–a systematic approach
OBJECTIVE: The prevalence of osteoarthritis (OA) increases dramatically in women after the
age of 50. Animal models are used to study the effects of hormone depletion [by ovariectomy …
age of 50. Animal models are used to study the effects of hormone depletion [by ovariectomy …
Primary osteoarthritis no longer primary: three subsets with distinct etiological, clinical, and therapeutic characteristics
G Herrero-Beaumont, JA Roman-Blas… - Seminars in arthritis and …, 2009 - Elsevier
BACKGROUND: Osteoarthritis (OA) has been historically divided into primary and
secondary. Primary OA has been defined as an idiopathic condition develo** in …
secondary. Primary OA has been defined as an idiopathic condition develo** in …
Can we identify patients with high risk of osteoarthritis progression who will respond to treatment? A focus on epidemiology and phenotype of osteoarthritis
Osteoarthritis is a syndrome affecting a variety of patient profiles. A European Society for
Clinical and Economic Aspects of Osteoporosis and Osteoarthritis and the European Union …
Clinical and Economic Aspects of Osteoporosis and Osteoarthritis and the European Union …
Dkk‐1–Mediated inhibition of Wnt signaling in bone ameliorates osteoarthritis in mice
T Funck‐Brentano, W Bouaziz, C Marty… - Arthritis & …, 2014 - Wiley Online Library
Objective Wnt signaling is a master regulator of joint homeostasis, but its role in
osteoarthritis (OA) remains unclear. This study was undertaken to characterize the activation …
osteoarthritis (OA) remains unclear. This study was undertaken to characterize the activation …