Proteogenomic data and resources for pan-cancer analysis

Y Li, Y Dou, FDV Leprevost, Y Geffen, AP Calinawan… - Cancer cell, 2023 - cell.com
Summary The National Cancer Institute's Clinical Proteomic Tumor Analysis Consortium
(CPTAC) investigates tumors from a proteogenomic perspective, creating rich multi-omics …

Signaling pathways in rheumatoid arthritis: implications for targeted therapy

Q Ding, W Hu, R Wang, Q Yang, M Zhu, M Li… - Signal transduction and …, 2023 - nature.com
Rheumatoid arthritis (RA) is an incurable systemic autoimmune disease. Disease
progression leads to joint deformity and associated loss of function, which significantly …

The role of microRNAs in neurodegenerative diseases: a review

S Li, Z Lei, T Sun - Cell biology and toxicology, 2023 - Springer
MicroRNAs (miRNAs) are non-coding RNAs which are essential post-transcriptional gene
regulators in various neuronal degenerative diseases and playact a key role in these …

MIENTURNET: an interactive web tool for microRNA-target enrichment and network-based analysis

V Licursi, F Conte, G Fiscon, P Paci - BMC bioinformatics, 2019 - Springer
Background miRNAs regulate the expression of several genes with one miRNA able to
target multiple genes and with one gene able to be simultaneously targeted by more than …

Liquid biopsies: applications for cancer diagnosis and monitoring

I Martins, IP Ribeiro, J Jorge, AC Gonçalves… - Genes, 2021 - mdpi.com
The minimally—or non-invasive detection of circulating tumor-derived components in
biofluids, such as blood, liquid biopsy is a revolutionary approach with significant potential …

The impact of diet on miRNA regulation and its implications for health: a systematic review

M DeLucas, J Sánchez, A Palou, F Serra - Nutrients, 2024 - mdpi.com
The evidence suggests that diet can modulate endogenous microRNA (miRNA) expression.
Changes in miRNA expression may affect metabolic processes and consequently be …

The progress and promise of RNA medicine─ an arsenal of targeted treatments

JM Sasso, BJB Ambrose, R Tenchov… - Journal of medicinal …, 2022 - ACS Publications
In the past decade, there has been a shift in research, clinical development, and commercial
activity to exploit the many physiological roles of RNA for use in medicine. With the rapid …

LncRNA MIR200CHG inhibits EMT in gastric cancer by stabilizing miR-200c from target-directed miRNA degradation

Y Zhu, C Huang, C Zhang, Y Zhou, E Zhao… - Nature …, 2023 - nature.com
Gastric cancer (GC) is a heterogeneous disease, threatening millions of lives worldwide, yet
the functional roles of long non-coding RNAs (lncRNAs) in different GC subtypes remain …

[HTML][HTML] Joint masking and self-supervised strategies for inferring small molecule-miRNA associations

Z Zhou, L Zhuo, X Fu, J Lv, Q Zou, R Qi - Molecular Therapy-Nucleic Acids, 2024 - cell.com
Inferring small molecule-miRNA associations (MMAs) is crucial for revealing the intricacies
of biological processes and disease mechanisms. Deep learning, renowned for its …

Mechanisms of miRNA‐mediated gene regulation from common downregulation to mRNA‐specific upregulation

A Valinezhad Orang, R Safaralizadeh… - … journal of genomics, 2014 - Wiley Online Library
Discovered in 1993, micoRNAs (miRNAs) are now recognized as one of the major
regulatory gene families in eukaryotes. To date, 24521 microRNAs have been discovered …